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. 1986 Dec;30(6):948–950. doi: 10.1128/aac.30.6.948

In vitro activity of A-56619 (difloxacin), A-56620, and other new quinolone antimicrobial agents against genital pathogens.

L D Liebowitz, J Saunders, G Fehler, R C Ballard, H J Koornhof
PMCID: PMC180627  PMID: 3101590

Abstract

The in vitro activities of two new carboxyquinolones, A-56619 (difloxacin) and A-56620, were compared with those of ciprofloxacin, norfloxacin, and ofloxacin against genital tract pathogens. All the quinolones were highly active against Neisseria gonorrhoeae. A-56619 had the lowest MICs against Chlamydia trachomatis (MIC range, 0.125 to 0.25 micrograms/ml) and Haemophilus ducreyi (MIC for 90% of isolates tested, 0.1 micrograms/ml).

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Selected References

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  1. Aznar J., Caballero M. C., Lozano M. C., de Miguel C., Palomares J. C., Perea E. J. Activities of new quinoline derivatives against genital pathogens. Antimicrob Agents Chemother. 1985 Jan;27(1):76–78. doi: 10.1128/aac.27.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bailey J. M., Heppleston C., Richmond S. J. Comparison of the in vitro activities of ofloxacin and tetracycline against Chlamydia trachomatis as assessed by indirect immunofluorescence. Antimicrob Agents Chemother. 1984 Jul;26(1):13–16. doi: 10.1128/aac.26.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barry A. L., Thornsberry C., Jones R. N. In vitro evaluation of A-56619 and A-56620, two new quinolones. Antimicrob Agents Chemother. 1986 Jan;29(1):40–43. doi: 10.1128/aac.29.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bilgeri Y. R., Ballard R. C., Duncan M. O., Mauff A. C., Koornhof H. J. Antimicrobial susceptibility of 103 strains of Haemophilus ducreyi isolated in Johannesburg. Antimicrob Agents Chemother. 1982 Oct;22(4):686–688. doi: 10.1128/aac.22.4.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Black F. T. Modifications of the growth inhibition test and its application to human T-mycoplasmas. Appl Microbiol. 1973 Apr;25(4):528–533. doi: 10.1128/am.25.4.528-533.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Crider S. R., Colby S. D., Miller L. K., Harrison W. O., Kerbs S. B., Berg S. W. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin. N Engl J Med. 1984 Jul 19;311(3):137–140. doi: 10.1056/NEJM198407193110301. [DOI] [PubMed] [Google Scholar]
  7. Fernandes P. B., Chu D. T., Bower R. R., Jarvis K. P., Ramer N. R., Shipkowitz N. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):201–208. doi: 10.1128/aac.29.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gadebusch H. H., Shungu D. L., Weinberg E., Chung S. K. Comparison of the antibacterial activity of norfloxacin (MK 0366, AM 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents. Infection. 1982 Jan;10(1):41–44. doi: 10.1007/BF01640837. [DOI] [PubMed] [Google Scholar]
  9. Heessen F. W., Muytjens H. L. In vitro activities of ciprofloxacin, norfloxacin, pipemidic acid, cinoxacin, and nalidixic acid against Chlamydia trachomatis. Antimicrob Agents Chemother. 1984 Jan;25(1):123–124. doi: 10.1128/aac.25.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heppleston C., Richmond S., Bailey J. Antichlamydial activity of quinolone carboxylic acids. J Antimicrob Chemother. 1985 May;15(5):645–647. doi: 10.1093/jac/15.5.645. [DOI] [PubMed] [Google Scholar]
  11. Khan M. Y., Siddiqui Y., Gruninger R. P. Comparative in vitro activity of Mk-0366 and other selected oral antimicrobial agents against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1981 Aug;20(2):265–266. doi: 10.1128/aac.20.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Loo P. S., Ridgway G. L., Oriel J. D. Single dose ciprofloxacin for treating gonococcal infections in men. Genitourin Med. 1985 Oct;61(5):302–305. doi: 10.1136/sti.61.5.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Peeters M., Van Dyck E., Piot P. In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1984 Oct;26(4):608–609. doi: 10.1128/aac.26.4.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ridgway G. L., Mumtaz G., Gabriel F. G., Oriel J. D. The activity of ciprofloxacin and other 4-quinolones against Chlamydia trachomatis and Mycoplasmas in vitro. Eur J Clin Microbiol. 1984 Aug;3(4):344–346. doi: 10.1007/BF01977491. [DOI] [PubMed] [Google Scholar]
  15. Ridgway G. L., Owen J. M., Oriel J. D. The antimicrobial susceptibility of Chlamydia trachomatis in cell culture. Br J Vener Dis. 1978 Apr;54(2):103–106. doi: 10.1136/sti.54.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rohlfing S. R., Landmesser J. E., Gerster J. F., Pecore S. E., Stern R. M. Differentiation of fluorinated quinolone antibacterials with Neisseria gonorrhoeae isolates. J Antimicrob Chemother. 1985 May;15(5):539–544. doi: 10.1093/jac/15.5.539. [DOI] [PubMed] [Google Scholar]
  17. Simon C., Lindner U. In vitro activity of norfloxacin against Mycoplasma hominis and Ureaplasma urealyticum. Eur J Clin Microbiol. 1983 Oct;2(5):479–480. doi: 10.1007/BF02013911. [DOI] [PubMed] [Google Scholar]
  18. Stamm J. M., Hanson C. W., Chu D. T., Bailer R., Vojtko C., Fernandes P. B. In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):193–200. doi: 10.1128/aac.29.2.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tartaglione T. A., Raffalovich A. C., Poynor W. J., Espinel-Ingroff A., Kerkering T. M. Pharmacokinetics and tolerance of ciprofloxacin after sequential increasing oral doses. Antimicrob Agents Chemother. 1986 Jan;29(1):62–66. doi: 10.1128/aac.29.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Taylor-Robinson D. Mycoplasmas of various hosts and their antibiotic sensitivities. Postgrad Med J. 1967 Mar;43(Suppl):100–104. [PubMed] [Google Scholar]

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