Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1981 Jan;19(1):134–138. doi: 10.1128/aac.19.1.134

Comparison of antibacterial and antiimmune effects of certain rifamycins.

J E Kasik, M Monick
PMCID: PMC181371  PMID: 6787977

Abstract

Comparison of the in vivo and in vitro immunosuppressive activities of the five rifamycins with their in vitro antibacterial and anti-ribonucleic acid polymerase activities indicated that correlation was poor. Examination of their activities on mitogen-induced blastogenesis in human peripheral blood leukocytes and inhibition of delayed-type hypersensitivity to partially purified protein derivative in immunized mice demonstrated that correlation was usually good. Antibacterial activity in cultures and the activities of the rifamycins inhibiting deoxyribonucleic acid-dependent ribonucleic acid polymerase appeared to correlate well. However, when these two types of activity, antiimmune and antibacterial, were compared, correlation was poor on occasion and indicated that the antiimmune activities and antibacterial activities of the rifamycins are probably not related.

Full text

PDF
134

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buss W. C., Kun E. Effects of rifampicin on RNA and protein synthesis in isolated rat liver mitochondria. Biochem Pharmacol. 1978;27(17):2139–2145. doi: 10.1016/0006-2952(78)90286-1. [DOI] [PubMed] [Google Scholar]
  2. Buss W. C., Morgan R., Guttmann J., Barela T., Stalter K. Rifampicin inhibition of protein synthesis in mammalian cells. Science. 1978 Apr 28;200(4340):432–434. doi: 10.1126/science.644307. [DOI] [PubMed] [Google Scholar]
  3. Dajani B. M., Kasik J. E., Thompson J. S. Effect of rifampin on the immune response in guinea pigs. Antimicrob Agents Chemother. 1973 Apr;3(4):451–455. doi: 10.1128/aac.3.4.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grassi G. G., Pozzi E. Effect of rifampicin on delayed-hypersensitivity reactions. J Infect Dis. 1972 Nov;126(5):542–544. doi: 10.1093/infdis/126.5.542. [DOI] [PubMed] [Google Scholar]
  5. Hui J., Gordon N., Kajioka R. Permeability barrier to rifampin in mycobacteria. Antimicrob Agents Chemother. 1977 May;11(5):773–779. doi: 10.1128/aac.11.5.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kasik J. E., Monick M., Thompson J. S. Immunosuppressant activity of the ansamycins. Antimicrob Agents Chemother. 1976 Mar;9(3):470–473. doi: 10.1128/aac.9.3.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lorian V., Finland M. In vitro effect of rifampin on mycobacteria. Appl Microbiol. 1969 Feb;17(2):202–207. doi: 10.1128/am.17.2.202-207.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mukerjee P., Schuldt S., Kasik J. E. Effect of rifampin on cutaneous hypersensitivity to purified protein derivative in humans. Antimicrob Agents Chemother. 1973 Dec;4(6):607–611. doi: 10.1128/aac.4.6.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nakamura Y., Yura T. Effects of rifampicin on synthesis and functional activity of DNA-dependent RNA polymerase in Escherichia coli. Mol Gen Genet. 1976 Jun 15;145(3):227–237. doi: 10.1007/BF00325817. [DOI] [PubMed] [Google Scholar]
  10. Nilsson B. S. Rifampicin: an immunosuppressant? Lancet. 1971 Aug 14;2(7720):374–374. doi: 10.1016/s0140-6736(71)90087-0. [DOI] [PubMed] [Google Scholar]
  11. Păunescu E. In vivo and in vitro suppression of humoral and cellular immunological response by rifampicin. Nature. 1970 Dec 19;228(5277):1188–1190. doi: 10.1038/2281188a0. [DOI] [PubMed] [Google Scholar]
  12. Rabussay D., Zillig W. A rifampicin resistent rna-polymerase from E. coli altered in the beta-subunit. FEBS Lett. 1969 Oct 21;5(2):104–106. doi: 10.1016/0014-5793(69)80305-4. [DOI] [PubMed] [Google Scholar]
  13. Thompson J. S., Parmely M. J., Flink R. J., Canady M. S., Severson C. D. Relationship of mixed lymphocyte culture response to HL-A histocompatibility antigens. Effect of allele plus one antigen match. J Exp Med. 1972 Mar 1;135(3):596–609. doi: 10.1084/jem.135.3.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tsukamura M. The pattern of resistance development to rifampicin in Mycobacterium tuberculosis. Tubercle. 1972 Jun;53(2):111–117. doi: 10.1016/0041-3879(72)90027-x. [DOI] [PubMed] [Google Scholar]
  15. VOGEL H. J., BONNER D. M. Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956 Jan;218(1):97–106. [PubMed] [Google Scholar]
  16. Wehrli W., Staehelin M. Actions of the rifamycins. Bacteriol Rev. 1971 Sep;35(3):290–309. doi: 10.1128/br.35.3.290-309.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES