Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1981 Jan;19(1):199–200. doi: 10.1128/aac.19.1.199

Increase in colony-forming units of Candida albicans after treatment with polyene antibiotics.

J Brajtburg, S Elberg, G Medoff, G S Kobayashi
PMCID: PMC181384  PMID: 7018385

Abstract

Polyene antibiotics, at concentrations which do not cause detectable toxic effect, induce an increase in the number of colon-forming units of yeast cells of Candida albicans. This effect, which we attribute to an increase in plating efficiency, is probably caused by binding of the polyenes to fatty acids in the cell wall of fungi.

Full text

PDF
199

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GHOSH A., GHOSH J. J. Factors affecting the absorption of nystatin by Candida albicans. Ann Biochem Exp Med. 1963 Mar;23:101–112. [PubMed] [Google Scholar]
  2. Gale E. F. The release of potassium ions from Candida albicans in the presence of polyene antibiotics. J Gen Microbiol. 1974 Feb;80(2):451–465. doi: 10.1099/00221287-80-2-451. [DOI] [PubMed] [Google Scholar]
  3. Gruda I., Nadeau P., Brajtburg J., Medoff G. Application of differential spectra in the ultraviolet-visible region to study the formation of amphotericin B-sterol complexes. Biochim Biophys Acta. 1980 Nov 4;602(2):260–268. doi: 10.1016/0005-2736(80)90309-0. [DOI] [PubMed] [Google Scholar]
  4. Hamilton-Miller J. M. Fungal sterols and the mode of action of the polyene antibiotics. Adv Appl Microbiol. 1974;17(0):109–134. doi: 10.1016/s0065-2164(08)70556-2. [DOI] [PubMed] [Google Scholar]
  5. Hammond S. M., Kliger B. N. Mode of action of the polyene antibiotic candicidin: binding factors in the wall of Candida albicans. Antimicrob Agents Chemother. 1976 Apr;9(4):561–568. doi: 10.1128/aac.9.4.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Iannitelli R. C., Ikawa M. Effect of fatty acids on action of polyene antibiotics. Antimicrob Agents Chemother. 1980 May;17(5):861–864. doi: 10.1128/aac.17.5.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kotler-Brajtburg J., Medoff G., Schlessinger D., Kobayashi G. S. Characterization of the binding of amphotericin B to Saccharomyces cerevisiae and relationship to the antifungal effects. Antimicrob Agents Chemother. 1974 Dec;6(6):770–776. doi: 10.1128/aac.6.6.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kuroda S., Uno J., Arai T. Target substances of some antifungal agents in the cell membrane. Antimicrob Agents Chemother. 1978 Mar;13(3):454–459. doi: 10.1128/aac.13.3.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  10. Little J. R., Plut E. J., Kotler-Brajtburg J., Medoff G., Kobayashi G. S. Relationship between the antibiotic and immunoadjuvant effects of amphotericin B methyl ester. Immunochemistry. 1978 Apr;15(4):219–224. doi: 10.1016/0161-5890(78)90058-5. [DOI] [PubMed] [Google Scholar]
  11. Norman A. W., Spielvogel A. M., Wong R. G. Polyene antibiotic - sterol interaction. Adv Lipid Res. 1976;14:127–170. [PubMed] [Google Scholar]
  12. Sud I. J., Chou D. L., Feingold D. S. Effect of free fatty acids on liposome susceptibility to imidazole antifungals. Antimicrob Agents Chemother. 1979 Nov;16(5):660–663. doi: 10.1128/aac.16.5.660. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES