Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1981 Feb;19(2):274–278. doi: 10.1128/aac.19.2.274

Macrolide-lincosamide-streptogramin resistance patterns in Clostridium perfringens from animals.

G N Dutta, L A Devriese
PMCID: PMC181408  PMID: 6289728

Abstract

Different patterns of resistance against commonly used macrolide, lincosamide, and streptogramin antibiotics were found in Clostridium perfringens of animal origin. The patterns were designated as (i) macrolide-lincosamide-streptogramin group B generalized resistance, (ii) macrolide-lincosamide generalized resistance, (iii) macrolide-lincosamide inducible resistance, and (iv) macrolide-lincosamide-streptogramin low-level generalized resistance. The strains of the fourth pattern were able to inactivate pristinamycin and virginiamycin. The macrolide-susceptible strains showed a bimodal distribution of lincomycin and clindamycin susceptibility levels. The susceptible strains were inhibited by 0.25 micrograms of lincomycin per ml and 0.03 micrograms of clindamycin per ml. The low-level resistant strains were inhibited at concentrations of 2 to 4 micrograms of lincomycin per ml and 0.5 to 2 micrograms of clindamycin per ml.

Full text

PDF
274

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBER M., WATERWORTH P. M. ANTIBACTERIAL ACTIVITY OF LINCOMYCIN AND PRISTINAMYCIN: A COMPARISON WITH ERYTHROMYCIN. Br Med J. 1964 Sep 5;2(5409):603–606. doi: 10.1136/bmj.2.5409.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bourse R., Monnier J. Effet de l'érythromycine sur la croissae de Staph. aureus "resistant dissocié" en bactériostase par un autre macrolide ou un antibiotique apparenté. Ann Inst Pasteur (Paris) 1967 Jul;113(1):67–79. [PubMed] [Google Scholar]
  3. CHABBERT Y. Antagonisme in vitro entre l'érythromycine et la spiramycine. Ann Inst Pasteur (Paris) 1956 Jun;90(6):787–790. [PubMed] [Google Scholar]
  4. Dublanchet A., Soussy C. J., Squinazi F., Duval J. Résistance de Staphylococcus aureus aux streptogramines. Ann Microbiol (Paris) 1977 Apr;128A(3):277–287. [PubMed] [Google Scholar]
  5. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  6. GARROD L. P. The erythromycin group of antibiotics. Br Med J. 1957 Jul 13;2(5036):57–63. doi: 10.1136/bmj.2.5036.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goffic F. L., Capmau M. L., Bonnet D., Cerceau C., Soussy C., Dublanchet A., Duval J. Plasmid-mediated pristinamycin resistance. PAC IIA: a new enzyme which modifies pristinamycin IIA. J Antibiot (Tokyo) 1977 Aug;30(8):665–669. doi: 10.7164/antibiotics.30.665. [DOI] [PubMed] [Google Scholar]
  8. Gots J. S. THE DETECTION OF PENICILLINASE-PRODUCING PROPERTIES OF MICROORGANISMS. Science. 1945 Sep 21;102(2647):309–309. doi: 10.1126/science.102.2647.309. [DOI] [PubMed] [Google Scholar]
  9. Hyder S. L., Streitfeld M. M. Inducible and constitutive resistance to macrolide antibiotics and lincomycin in clinically isolated strains of Streptococcus pyogenes. Antimicrob Agents Chemother. 1973 Sep;4(3):327–331. doi: 10.1128/aac.4.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Le Goffic F., Capmau M. L., Abbe J., Cerceau C., Dublanchet A., Duval J. Plasmid mediated pristinamycin resistance: PH 1A, a pristinamycin 1A hydrolase. Ann Microbiol (Paris) 1977 Nov-Dec;128B(4):471–474. [PubMed] [Google Scholar]
  11. McDonald M. C., Biberstein E. L. Determination of bacterial susceptibility to tylosin by single-disk agar diffusion tests. Am J Vet Res. 1974 Dec;35(12):1563–1565. [PubMed] [Google Scholar]
  12. Rood J. I., Maher E. A., Somers E. B., Campos E., Duncan C. L. Isolation and characterization of multiply antibiotic-resistant Clostridum perfringens strains from porcine feces. Antimicrob Agents Chemother. 1978 May;13(5):871–880. doi: 10.1128/aac.13.5.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sapico F. L., Kwok Y. Y., Sutter V. L., Finegold S. M. Standardized antimicrobial disc susceptibility testing of anaerobic bacteria: in vitro susceptibility of Clostridium perfringens to nine antibiotics. Antimicrob Agents Chemother. 1972 Oct;2(4):320–325. doi: 10.1128/aac.2.4.320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sebald M., Bouanchaud D., Bieth G., Prévot A. R. Nature plasmidique de la résistance à plusieurs antibiotiques chez C. perfringens type A, souche 659. C R Acad Sci Hebd Seances Acad Sci D. 1975 May 26;280(20):2401–2404. [PubMed] [Google Scholar]
  15. Sebald M., Bréfort M. G. Transfert du plasmide Tétracycline-Chloramphénicol chez Clostridium perfringens. C R Acad Sci Hebd Seances Acad Sci D. 1975 Jul 28;281(4):317–319. [PubMed] [Google Scholar]
  16. Sutter V. L., Barry A. L., Wilkins T. D., Zabransky R. J. Collaborative evaluation of a proposed reference dilution method of susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1979 Oct;16(4):495–502. doi: 10.1128/aac.16.4.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WEAVER J. R., PATTEE P. A. INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS. J Bacteriol. 1964 Sep;88:574–580. doi: 10.1128/jb.88.3.574-580.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Weisblum B., Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: survey of antibiotic classes involved. J Bacteriol. 1969 May;98(2):447–452. doi: 10.1128/jb.98.2.447-452.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Weisblum B., Siddhikol C., Lai C. J., Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction. J Bacteriol. 1971 Jun;106(3):835–847. doi: 10.1128/jb.106.3.835-847.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wilkins T. D., Chalgren S. Medium for use in antibiotic susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1976 Dec;10(6):926–928. doi: 10.1128/aac.10.6.926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wilkins T. D., Thiel T. Resistance of some species of Clostridium to clindamycin. Antimicrob Agents Chemother. 1973 Jan;3(1):136–137. doi: 10.1128/aac.3.1.136. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES