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. 1981 Feb;19(2):290–293. doi: 10.1128/aac.19.2.290

Effect of antibiotics on the prevalence of enterotoxigenic Escherichia coli in two populations in the Philippines.

P Echeverria, P A Mejia, C Duangmani
PMCID: PMC181411  PMID: 6751218

Abstract

Hostesses and restaurant employees in the Philippines were studied to determine whether an increased use of antibiotics was associated with a higher point prevalence of enterotoxigenic Escherichia coli. Of 1,030 hostesses and 628 restaurant employees, 28 and 4%, respectively, said that they had taken antibiotics within a week of being cultured (P less than 0.001). Of hostesses and restaurant employees, 10% (103 of 1,030) and 2% (14 of 628), respectively, had antibiotics detectable in their urine (P less than 0.001). Enterotoxigenic E. coli strains were isolated from 1.2% (12 of 1,030) of hostesses and 1.7% (11 of 628) of restaurant employees. In both populations, enterotoxigenic E. coli strains were never found in subjects who had antibacterial activity in their urine. Although resistance to two or more antibiotics was found more frequently in E. coli isolated from hostesses than in that isolated from restaurant workers (48 versus 33%; P less than 0.01), antibiotic selective pressure did not increase the prevalence of enterotoxigenic E. coli in these two populations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aserkoff B., Bennett J. V. Effect of antibiotic therapy in acute salmonellosis on the fecal excretion of salmonellae. N Engl J Med. 1969 Sep 18;281(12):636–640. doi: 10.1056/NEJM196909182811202. [DOI] [PubMed] [Google Scholar]
  2. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  3. Byers P. A., DuPont H. L. Pooling method for screening large numbers of Escherichia coli for production of heat-stable enterotoxin, and its application in field studies. J Clin Microbiol. 1979 Apr;9(4):541–543. doi: 10.1128/jcm.9.4.541-543.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dean A. G., Ching Y. C., Williams R. G., Harden L. B. Test for Escherichia coli enterotoxin using infant mice: application in a study of diarrhea in children in Honolulu. J Infect Dis. 1972 Apr;125(4):407–411. doi: 10.1093/infdis/125.4.407. [DOI] [PubMed] [Google Scholar]
  5. Echeverria P., Ho M. T., Blacklow N. R., Quinnan G., Portnoy B., Olson J. G., Conklin R., DuPont H. L., Cross J. H. Relative importance of viruses and bacteria in the etiology of pediatric diarrhea in Taiwan. J Infect Dis. 1977 Sep;136(3):383–390. doi: 10.1093/infdis/136.3.383. [DOI] [PubMed] [Google Scholar]
  6. Echeverria P., Verhaert L., Ulyangco C. V., Komalarini S., Ho M. T., Orskov F., Orskov I. Antimicrobial resistance and enterotoxin production among isolates of Escherichia coli in the Far East. Lancet. 1978 Sep 16;2(8090):589–592. doi: 10.1016/s0140-6736(78)92820-9. [DOI] [PubMed] [Google Scholar]
  7. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  8. Gyles C. L., Palchaudhuri S., Maas W. K. Naturally occurring plasmid carrying genes for enterotoxin production and drug resistance. Science. 1977 Oct 14;198(4313):198–199. doi: 10.1126/science.333581. [DOI] [PubMed] [Google Scholar]
  9. Gyles C., So M., Falkow S. The enterotoxin plasmids of Escherichia coli. J Infect Dis. 1974 Jul;130(1):40–49. doi: 10.1093/infdis/130.1.40. [DOI] [PubMed] [Google Scholar]
  10. McConnell M. M., Willshaw G. A., Smith H. R., Scotland S. M., Rowe B. Transposition of ampicillin resistance to an enterotoxin plasmid in an Escherichia coli strain of human origin. J Bacteriol. 1979 Aug;139(2):346–355. doi: 10.1128/jb.139.2.346-355.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Merson M. H., Sack R. B., Kibriya A. K., Al-Mahmood A., Adamed Q. S., Huq I. Use of colony pools for diagnosis of enterotoxigenic Escherichia coli diarrhea. J Clin Microbiol. 1979 Apr;9(4):493–497. doi: 10.1128/jcm.9.4.493-497.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ryder R. W., Sack D. A., Kapikian A. Z., McLaughlin J. C., Chakraborty J., Mizanur Rahman A. S., Merson M. H., Wells J. G. Enterotoxigenic Escherichia coli and Reovirus-like agent in rural Bangladesh. Lancet. 1976 Mar 27;1(7961):659–663. doi: 10.1016/s0140-6736(76)92776-8. [DOI] [PubMed] [Google Scholar]
  13. Sack D. A., Sack R. B. Test for enterotoxigenic Escherichia coli using Y-1 adrenal cells in miniculture. Infect Immun. 1975 Feb;11(2):334–336. doi: 10.1128/iai.11.2.334-336.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sack R. B., Gorbach S. L., Banwell J. G., Jacobs B., Chatterjee B. D., Mitra R. C. Enterotoxigenic Escherichia coli isolated from patients with severe cholera-like disease. J Infect Dis. 1971 Apr;123(4):378–385. doi: 10.1093/infdis/123.4.378. [DOI] [PubMed] [Google Scholar]
  15. Smith H. W., Linggood M. A. Observations on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea. J Med Microbiol. 1971 Nov;4(4):467–485. doi: 10.1099/00222615-4-4-467. [DOI] [PubMed] [Google Scholar]
  16. Smith H. W., Linggood M. A. Transfer factors in Escherichia coli with particular regard to their incidence in enteropathogenic strains. J Gen Microbiol. 1970 Aug;62(3):287–299. doi: 10.1099/00221287-62-3-287. [DOI] [PubMed] [Google Scholar]
  17. Smith H. W. The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs. J Med Microbiol. 1970 Feb;3(1):165–180. doi: 10.1099/00222615-3-1-165. [DOI] [PubMed] [Google Scholar]

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