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. 1981 Mar;19(3):487–489. doi: 10.1128/aac.19.3.487

Filament formation of Fusobacterium nucleatum cells induced by mecillinam.

T Onoe, T Umemoto, H Sagawa, H Suginaka
PMCID: PMC181458  PMID: 6264847

Abstract

Subinhibitory concentrations of mecillinam transformed Fusobacterium nucleatum cells into a marked filament form, quite different from a spherical form demonstrated in Escherichia coli.

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Selected References

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  1. Chase H. A., Reynolds P. E., Ward J. B. Purification and characterization of the penicillin-binding protein that is the lethal target of penicillin in Bacillus megaterium and Bacillus licheniformis. Protein exchange and complex stability. Eur J Biochem. 1978 Jul 17;88(1):275–285. doi: 10.1111/j.1432-1033.1978.tb12448.x. [DOI] [PubMed] [Google Scholar]
  2. Coyette J., Ghuysen J. M., Fontana R. Solubilization and isolation of the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC9790. Properties of the purified enzyme. Eur J Biochem. 1978 Jul 17;88(1):297–305. doi: 10.1111/j.1432-1033.1978.tb12450.x. [DOI] [PubMed] [Google Scholar]
  3. Curtis N. A., Orr D., Ross G. W., Boulton M. G. Competition of beta-lactam antibiotics for the penicillin-binding proteins of Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella aerogenes, Proteus rettgeri, and Escherichia coli: comparison with antibacterial activity and effects upon bacterial morphology. Antimicrob Agents Chemother. 1979 Sep;16(3):325–328. doi: 10.1128/aac.16.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greenwood D., O'Grady F. Antibiotic-induced surface changes in microorganisms demonstrated by scanning electron microscopy. Science. 1969 Mar 7;163(3871):1076–1078. doi: 10.1126/science.163.3871.1076. [DOI] [PubMed] [Google Scholar]
  5. Greenwood D., O'Grady F. FL 1060: a new beta-lactam antibiotic with novel properties. J Clin Pathol. 1973 Jan;26(1):1–6. doi: 10.1136/jcp.26.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Iida K., Hirata S., Nakamuta S., Koike M. Inhibition of cell division of Escherichia coli by a new synthetic penicillin, piperacillin. Antimicrob Agents Chemother. 1978 Aug;14(2):257–266. doi: 10.1128/aac.14.2.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kozarich J. W., Strominger J. L. A membrane enzyme from Staphylococcus aureus which catalyzes transpeptidase, carboxypeptidase, and penicillinase activities. J Biol Chem. 1978 Feb 25;253(4):1272–1278. [PubMed] [Google Scholar]
  8. Lederberg J. BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN. Proc Natl Acad Sci U S A. 1956 Sep;42(9):574–577. doi: 10.1073/pnas.42.9.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Melchior N. H., Blom J., Tybring L., Birch-Andersen A. Light and electron microscopy of the early response of Escherichia coli to a 6beta-amidinopenicillanic acid (FL 1060). Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Aug;81(4):393–407. doi: 10.1111/j.1699-0463.1973.tb02222.x. [DOI] [PubMed] [Google Scholar]
  10. Muggleton P. W., O'Callaghan C. H., Foord R. D., Kirby S. M., Ryan D. M. Laoratory appraisal of cephalexin. Antimicrob Agents Chemother (Bethesda) 1968;8:353–360. [PubMed] [Google Scholar]
  11. Noguchi H., Matsuhashi M., Mitsuhashi S. Comparative studies of penicillin-binding proteins in Pseudomonas aeruginosa and Escherichia coli. Eur J Biochem. 1979 Oct;100(1):41–49. doi: 10.1111/j.1432-1033.1979.tb02031.x. [DOI] [PubMed] [Google Scholar]
  12. Ohya S., Yamazaki M., Sugawara S., Matsuhashi M. Penicillin-binding proteins in Proteus species. J Bacteriol. 1979 Jan;137(1):474–479. doi: 10.1128/jb.137.1.474-479.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Reeves D. S., Wise R., Bywater M. J. A laboratory evaluation of a novel (beta-lactam antibiotic mecillinam. J Antimicrob Chemother. 1975 Sep;1(3):337–344. doi: 10.1093/jac/1.3.337. [DOI] [PubMed] [Google Scholar]
  14. Rodriguez W. J., Saz A. K. Differential binding of penicillin by membrane fractions from penicillin-susceptible and -resistant gonococci. Antimicrob Agents Chemother. 1978 Apr;13(4):589–597. doi: 10.1128/aac.13.4.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shepherd S. T., Chase H. A., Reynolds P. E. The separation and properties of two penicillin-binding proteins from Salmonella typhimurium. Eur J Biochem. 1977 Sep;78(2):521–523. doi: 10.1111/j.1432-1033.1977.tb11765.x. [DOI] [PubMed] [Google Scholar]
  16. Spratt B. G. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999–3003. doi: 10.1073/pnas.72.8.2999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Suginaka H., Blumberg P. M., Strominger J. L. Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. J Biol Chem. 1972 Sep 10;247(17):5279–5288. [PubMed] [Google Scholar]

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