Abstract
Thioglycerol inhibits the growth of various Escherichia coli strains and other microorganisms, both gram positive and gram negative. The susceptibility of organisms varies. The bactericidal action of this substance is not continuous and stops after an initial burst. At subbactericidal concentrations synthesis of ribonucleic acid is the most strongly affected. This is not due to interference with nucleoside biosynthesis or to direct inhibition of ribonucleic acid polymerase by thioglycerol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ames G. F. Lipids of Salmonella typhimurium and Escherichia coli: structure and metabolism. J Bacteriol. 1968 Mar;95(3):833–843. doi: 10.1128/jb.95.3.833-843.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bell R. M. Mutants of Escherichia coli defective in membrane phospholipid synthesis: macromolecular synthesis in an sn-glycerol 3-phosphate acyltransferase Km mutant. J Bacteriol. 1974 Mar;117(3):1065–1076. doi: 10.1128/jb.117.3.1065-1076.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Broome J. D., Jeng M. W. Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes. J Exp Med. 1973 Sep 1;138(3):574–592. doi: 10.1084/jem.138.3.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burgess R. R., Jendrisak J. J. A procedure for the rapid, large-scall purification of Escherichia coli DNA-dependent RNA polymerase involving Polymin P precipitation and DNA-cellulose chromatography. Biochemistry. 1975 Oct 21;14(21):4634–4638. doi: 10.1021/bi00692a011. [DOI] [PubMed] [Google Scholar]
- DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gniazdowski M., Szmigiero L., Slaska K., Jaros-Kamińska B., Ciesielska E. Influence of thiols on inhibition of ribonucleic acid synthesis in vitro by a 1-nitro-9-aminoalkylacridine derivative, C-283. Mol Pharmacol. 1975 May;11(3):310–318. [PubMed] [Google Scholar]
- Goodman M. G., Weigle W. O. Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol. J Exp Med. 1977 Mar 1;145(3):473–489. doi: 10.1084/jem.145.3.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Javor G. T. Stimulation of unbalanced ribonucleic acid synthesis in Escherichia coli by methanol. J Bacteriol. 1972 Apr;110(1):179–185. doi: 10.1128/jb.110.1.179-185.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LALLIER R. [The effect of thiosorbitol and thioglycerol on the structure of the mitotic apparatus in the sea urchin egg (Paracentrotus lividus)]. J Cell Biol. 1962 Nov;15:382–384. doi: 10.1083/jcb.15.2.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LIMBOSCH-ROLIN S. [The effects of beta-mercaptoethanol and dithiodiglycol on the growth of Escherichia coli and Saccharomyces cerevisiae]. Exp Cell Res. 1963 Jan;29:61–72. doi: 10.1016/0014-4827(63)90358-6. [DOI] [PubMed] [Google Scholar]
- REVEL H. R., LURIA S. E., ROTMAN B. Biosynthesis of B-D-galactosidase controlled by phage-carried genes. I. Induced beta-D-galactosidase biosynthesis after transduction of gene z-plus by phage. Proc Natl Acad Sci U S A. 1961 Dec 15;47:1956–1967. doi: 10.1073/pnas.47.12.1956. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schild H. O. Lack of antagonism between thioglycerol and an oxytocin analogue not containing a disulphide bond. Br J Pharmacol. 1970 May;39(1):69–72. [PMC free article] [PubMed] [Google Scholar]
- Vargaftig B. B., Tranier Y., Chignard M. Inhibition by sulfhydryl agents of arachidonic acid-induced platelet aggregation and release of potential inflammatory substances. Prostaglandins. 1974 Oct 25;8(2):133–156. doi: 10.1016/0090-6980(74)90076-8. [DOI] [PubMed] [Google Scholar]