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. 1981 Apr;19(4):672–674. doi: 10.1128/aac.19.4.672

Combined Antiviral Effect of Interferon and Acyclovir on Herpes Simplex Virus Types 1 and 2

Trevor L Stanwick 1,†, Raymond F Schinazi 1, Donald E Campbell 1, Andre J Nahmias 1
PMCID: PMC181499  PMID: 6166248

Abstract

Acyclovir and human interferon displayed an additive to synergistic effect in reducing the number of herpes simplex viral plaque-forming units in Vero cells, suggesting a therapeutic potential for such combination therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryson Y. J., Kronenberg L. H. Combined antiviral effects of interferon, adenine, arabinoside, hypoxanthine arabinoside, and adenine arabinoside-5'-monophosphate in human fibroblast cultures. Antimicrob Agents Chemother. 1977 Feb;11(2):299–306. doi: 10.1128/aac.11.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CANTELL K., TOMMILA V. Effect of interferon on experimental vaccinia and herpes-simplex virus infections in rabbits' eyes. Lancet. 1960 Sep 24;2(7152):682–684. doi: 10.1016/s0140-6736(60)91751-7. [DOI] [PubMed] [Google Scholar]
  3. Dunnick J. K., Galasso G. J. Clinical trials with exogenous interferon: summary of a meeting. J Infect Dis. 1979 Jan;139(1):109–123. doi: 10.1093/infdis/139.1.109. [DOI] [PubMed] [Google Scholar]
  4. Ejercito P. M., Kieff E. D., Roizman B. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol. 1968 May;2(3):357–364. doi: 10.1099/0022-1317-2-3-357. [DOI] [PubMed] [Google Scholar]
  5. Field H. J., Bell S. E., Elion G. B., Nash A. A., Wildy P. Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice. Antimicrob Agents Chemother. 1979 Apr;15(4):554–561. doi: 10.1128/aac.15.4.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Glasgow L. A., Hanshaw J. B., Merigan T. C., Petralli J. K. Interferon and cytomegalovirus in vivo and in vitro. Proc Soc Exp Biol Med. 1967 Jul;125(3):843–849. doi: 10.3181/00379727-125-32220. [DOI] [PubMed] [Google Scholar]
  7. Jones B. R., Coster D. J., Fison P. N., Thompson G. M., Cobo L. M., Falcon M. G. Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers. Lancet. 1979 Feb 3;1(8110):243–244. doi: 10.1016/s0140-6736(79)90769-4. [DOI] [PubMed] [Google Scholar]
  8. Kaufman H. E., Varnell E. D., Centifanto Y. M., Rheinstrom S. D. Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits. Antimicrob Agents Chemother. 1978 Dec;14(6):842–845. doi: 10.1128/aac.14.6.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Klein R. J., Friedman-Kien A. E., DeStefano E. Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine. Antimicrob Agents Chemother. 1979 May;15(5):723–729. doi: 10.1128/aac.15.5.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lerner A. M., Bailey E. J. Differential sensitivity of herpes simplex virus types 1 and 2 to human interferon: antiviral effects of interferon plus 9-beta-D-arabinofuranosyladenine. J Infect Dis. 1976 Oct;134(4):400–404. doi: 10.1093/infdis/134.4.400. [DOI] [PubMed] [Google Scholar]
  11. Park N. H., Pavan-Langston D., McLean S. L. Acylovir in oral and ganglionic herpes simplex virus infections. J Infect Dis. 1979 Nov;140(5):802–806. doi: 10.1093/infdis/140.5.802. [DOI] [PubMed] [Google Scholar]
  12. Pazin G. J., Armstrong J. A., Lam M. T., Tarr G. C., Jannetta P. J., Ho M. Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root. N Engl J Med. 1979 Aug 2;301(5):225–230. doi: 10.1056/NEJM197908023010501. [DOI] [PubMed] [Google Scholar]
  13. Rasmussen L., Farley L. B. Inhibition of Herpesvirus hominis replication by human interferon. Infect Immun. 1975 Jul;12(1):104–108. doi: 10.1128/iai.12.1.104-108.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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