Abstract
The fluoro and chloro analogs of glycerol 3-phosphate inhibit the growth of Escherichia coli and affect bacterial enzymes involved in lipid synthesis.
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Selected References
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- Argast M., Boos W. Purification and properties of the sn-glycerol 3-phosphate-binding protein of Escherichia coli. J Biol Chem. 1979 Nov 10;254(21):10931–10935. [PubMed] [Google Scholar]
- Argast M., Ludtke D., Silhavy T. J., Boos W. A second transport system for sn-glycerol-3-phosphate in Escherichia coli. J Bacteriol. 1978 Dec;136(3):1070–1083. doi: 10.1128/jb.136.3.1070-1083.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheng P. J., Nunn W. D., Tyhach R. J., Goldstein S. L., Engel R., Tropp B. E. Investigations concerning the mode of action of 3,4-dihydroxybutyl-1-phosphonate on Escherichia coli. J Biol Chem. 1975 Mar 10;250(5):1633–1639. [PubMed] [Google Scholar]
- Fondy T. P., Ghangas G. S., Reza M. J. Synthesis of 1-halo analogs of DL-glycerol 3-phosphate and their effects on glycerol phosphate dehydrogenase. Biochemistry. 1970 Aug 4;9(16):3272–3280. doi: 10.1021/bi00818a022. [DOI] [PubMed] [Google Scholar]
- GAREN A., LEVINTHAL C. A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. I. Purification and characterization of alkaline phosphatase. Biochim Biophys Acta. 1960 Mar 11;38:470–483. doi: 10.1016/0006-3002(60)91282-8. [DOI] [PubMed] [Google Scholar]
- Ghangas G. S., Fondy T. P. Stereospecific synthesis of D-1-fluorodeoxyglycerol 3-phosphate and its effects on glycerol 3-phosphate dehydrogenase. Biochemistry. 1971 Aug 17;10(17):3204–3210. doi: 10.1021/bi00793a007. [DOI] [PubMed] [Google Scholar]
- Guth A., Engel R., Tropp B. E. Uptake of glycerol 3-phosphate and some of its analogs by the hexose phosphate transport system of Escherichia coli. J Bacteriol. 1980 Jul;143(1):538–539. doi: 10.1128/jb.143.1.538-539.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAYASHI S., KOCH J. P., LIN E. C. ACTIVE TRANSPORT OF L-ALPHA-GLYCEROPHOSPHATE IN ESCHERICHIA COLI. J Biol Chem. 1964 Sep;239:3098–3105. [PubMed] [Google Scholar]
- Hartman F. C., Gracy R. W. An active-site peptide from human triose phosphate isomerase. Biochem Biophys Res Commun. 1973 May 15;52(2):388–393. doi: 10.1016/0006-291x(73)90723-7. [DOI] [PubMed] [Google Scholar]
- Hartman F. C. Haloacetol phosphates. Characterization of the active site of rabbit muscle triose phosphate isomerase. Biochemistry. 1971 Jan 5;10(1):146–154. doi: 10.1021/bi00777a021. [DOI] [PubMed] [Google Scholar]
- Hartman F. C. Haloacetol phosphates. Potential active-site reagents for aldolase, triose phosphate isomerase, and glycerophosphate dehydrogenase. I. Preparation and properties. Biochemistry. 1970 Apr 14;9(8):1776–1782. doi: 10.1021/bi00810a017. [DOI] [PubMed] [Google Scholar]
- Hartman F. C. Haloacetol phosphates. Potential active-site reagents for aldolase, triose phosphate isomerase, and glycerophosphate dehydrogenase. II. Inactivation of aldolase. Biochemistry. 1970 Apr 14;9(8):1783–1791. doi: 10.1021/bi00810a018. [DOI] [PubMed] [Google Scholar]
- Leifer Z., Engel R., Tropp B. E. Transport of 3,4-dihydroxybutyl-1-phosphonate, an analogue of sn-glycerol 3-phosphate. J Bacteriol. 1977 May;130(2):968–971. doi: 10.1128/jb.130.2.968-971.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lin Y., Kobes D., Norton I. L., Hartman F. C. Affinity labeling of yeast aldolase by haloacetol phosphates. Biochem Biophys Res Commun. 1971 Oct 1;45(1):34–42. doi: 10.1016/0006-291x(71)90046-5. [DOI] [PubMed] [Google Scholar]
- Shopsis C. S., Engel R., Tropp B. E. Effects of phosphonic acid analogues of glycerol-3-phosphate on the growth of Escherichia coli. J Bacteriol. 1972 Oct;112(1):408–412. doi: 10.1128/jb.112.1.408-412.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shopsis C. S., Engel R., Tropp B. E. The inhibition of phosphatidylglycerol synthesis in Escherichia coli by 3,4-dihydroxybutyl-1-phosphonate. J Biol Chem. 1974 Apr 25;249(8):2473–2477. [PubMed] [Google Scholar]
- Silverman J. B., Babiarz P. S., Mahajan K. P., Buschek J., Fondy T. P. 1-Halo analogs of dihydroxyacetone 3-phosphate. The effects of the fluoro analog on cytosolic glycerol-3-phosphate dehydrogenase and triosephosphate isomerase. Biochemistry. 1975 May 20;14(10):2252–2258. doi: 10.1021/bi00681a033. [DOI] [PubMed] [Google Scholar]
- Tang C. T., Engel R., Tropp B. E. Glycerol 3-phosphate analogues as metabolic inhibitors in Escherichia coli, 3-hydroxy-4-oxobutyl-1-phosphonate, a drug that interferes with normal phosphoglyceride metabolism. Biochim Biophys Acta. 1979 Mar 29;572(3):472–482. doi: 10.1016/0005-2760(79)90154-1. [DOI] [PubMed] [Google Scholar]
- Tang C. T., Engel R., Tropp B. E. L-Glyceraldehude 3-phosphate, a bactericidal agent. Antimicrob Agents Chemother. 1977 Jan;11(1):147–153. doi: 10.1128/aac.11.1.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tyhach R. J., Engel R., Tropp B. E. Metabolic fate of 3,4-dihydroxybutyl-1-phosphonate in Escherichia coli. J Biol Chem. 1976 Nov 10;251(21):6717–6723. [PubMed] [Google Scholar]
- Yuan P. M., Gracy R. W., Hartman F. C. Haloacetol phosphates as affinity labels for methylglyoxal synthase. Biochem Biophys Res Commun. 1977 Feb 7;74(3):1007–1013. doi: 10.1016/0006-291x(77)91618-7. [DOI] [PubMed] [Google Scholar]