Abstract
Cefoperazone (10 mg/kg) and cephalothin (20 mg/kg) administered intramuscularly every 6 h were both effective in reducing the number of Staphylococcus aureus cells in vegetations in rabbits with endocarditis. Cefoperazone produced higher peak concentrations and greater bactericidal activity in serum than did cephalothin. Cefoperazone (40 mg/kg) administered every 6 h was significantly more effective than cefamandole (40 mg/kg) administered every 6 h in reducing the number of Enterobacter aerogenes cells in vegetations. Although cefamandole produced higher peak concentrations in serum, the serum bactericidal activity was greater with cefoperazone. The half-lives in serum were 0.64 h for cefoperazone and 0.46 h for cephalothin and cefamandole.
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Selected References
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- Barza M., Melethil S., Berger S., Ernst E. C. Comparative pharmacokinetics of cefamandole, cephapirin, and cephalothin in healthy subjects and effect of repeated dosing. Antimicrob Agents Chemother. 1976 Sep;10(3):421–425. doi: 10.1128/aac.10.3.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrizosa J., Kaye D. Antibiotic concentrations in serum, serum bactericidal activity, and results of therapy of streptococcal endocarditis in rabbits. Antimicrob Agents Chemother. 1977 Oct;12(4):479–483. doi: 10.1128/aac.12.4.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrizosa J., Kaye D. Antibiotic synergism in enterococcal endocarditis. J Lab Clin Med. 1976 Jul;88(1):132–141. [PubMed] [Google Scholar]
- Carrizosa J., Santoro J., Kaye D. Treatment of experimental Staphylococcus aureus endocarditis: comparison of cephalothin, cefazolin, and methicillin. Antimicrob Agents Chemother. 1978 Jan;13(1):74–77. doi: 10.1128/aac.13.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Petersdorf R. G. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J Clin Invest. 1973 Mar;52(3):592–598. doi: 10.1172/JCI107220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gerding D. N., Kozak A. J., Peterson L. R., Hall W. H. Failure of single doses of cefazolin and cefamandole to penetrate experimental chronic Escherichia coli abdominal abscesses. Antimicrob Agents Chemother. 1980 Jun;17(6):1023–1029. doi: 10.1128/aac.17.6.1023. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kunin C. M. A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels. Ann Intern Med. 1967 Jul;67(1):151–158. doi: 10.7326/0003-4819-67-1-151. [DOI] [PubMed] [Google Scholar]
- Levison M. E., Levison S. P., Ries K., Kaye D. Pharmacology of cefazolin in patients with normal and abnormal renal function. J Infect Dis. 1973 Oct;128(Suppl):S354–S357. doi: 10.1093/infdis/128.supplement_2.s354. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Fu K. P., Aswapokee N., Aswapokee P., Kung K. Comparative activity and beta-lactamase stability of cefoperazone, a piperazine cephalosporin. Antimicrob Agents Chemother. 1979 Aug;16(2):150–157. doi: 10.1128/aac.16.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WICK W. E., BONIECE W. S. IN VITRO AND IN VIVO LABORATORY EVALUATION OF CEPHALOGLYCIN AND CEPHALORIDINE. Appl Microbiol. 1965 Mar;13:248–253. doi: 10.1128/am.13.2.248-253.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]