Abstract
The susceptibilities of 12 strains of enterococci and 10 stains of Listeria monocytogenes to N-formimidoyl thienamycin were determined by a standard broth dilution method. Minimal inhibitory concentrations for L. monocytogenes strains were less than 0.25 micrograms/ml. As a group, strains of Streptococcus faecium were less susceptible than Streptococcus faecalis strains, but even for the latter, the minimal inhibitory concentrations were slightly greater than those previously reported. Minimal bactericidal concentrations against all organisms were many-fold higher than the corresponding inhibitory concentrations. In time-kill studies, combinations of N-formimidoyl thienamycin with gentamicin were synergistic against (or they completely sterilized cultures of) all the enterococcal strains and nine to 10 strains of L. monocytogenes. The magnitude of killing by the combinations was comparable to that previously observed with penicillin-gentamicin combinations. N-Formimidoyl thienamycin-tobramycin combinations were synergistic against those strains of S. faecalis and L. monocytogenes tested, but not against those of S. faecium.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Edmiston C. E., Jr, Gordon R. C. Evaluation of gentamicin and penicillin as a synergistic combination in experimental murine listeriosis. Antimicrob Agents Chemother. 1979 Dec;16(6):862–863. doi: 10.1128/aac.16.6.862. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glew R. H., Moellering R. C., Jr Effect of protein binding on the activity of penicillins in combination with gentamicin against enterococci. Antimicrob Agents Chemother. 1979 Jan;15(1):87–92. doi: 10.1128/aac.15.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kahan J. S., Kahan F. M., Goegelman R., Currie S. A., Jackson M., Stapley E. O., Miller T. W., Miller A. K., Hendlin D., Mochales S. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties. J Antibiot (Tokyo) 1979 Jan;32(1):1–12. doi: 10.7164/antibiotics.32.1. [DOI] [PubMed] [Google Scholar]
- Kesado T., Hashizume T., Asahi Y. Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics. Antimicrob Agents Chemother. 1980 Jun;17(6):912–917. doi: 10.1128/aac.17.6.912. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim K. S., Yoshimori R. N., Imagawa D. T., Anthony B. F. Importance of medium in demonstrating penicillin tolerance by group B streptococci. Antimicrob Agents Chemother. 1979 Aug;16(2):214–216. doi: 10.1128/aac.16.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krogstad D. J., Pargwette A. R. Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall. Antimicrob Agents Chemother. 1980 Jun;17(6):965–968. doi: 10.1128/aac.17.6.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kropp H., Sundelof J. G., Kahan J. S., Kahan F. M., Birnbaum J. MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities. Antimicrob Agents Chemother. 1980 Jun;17(6):993–1000. doi: 10.1128/aac.17.6.993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCracken G. H., Jr, Nelson J. D., Thomas M. L. Discrepancy between carbenicillin and ampicillin activities against enterococci and Listeria. Antimicrob Agents Chemother. 1973 Mar;3(3):343–349. doi: 10.1128/aac.3.3.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moellering R. C., Jr, Korzeniowski O. M., Sande M. A., Wennersten C. B. Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis. J Infect Dis. 1979 Aug;140(2):203–208. doi: 10.1093/infdis/140.2.203. [DOI] [PubMed] [Google Scholar]
- Moellering R. C., Jr, Medoff G., Leech I., Wennersten C., Kunz L. J. Antibiotic synergism against Listeria monocytogenes. Antimicrob Agents Chemother. 1972 Jan;1(1):30–34. doi: 10.1128/aac.1.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mohan K., Gordon R. C., Beaman T. C., Belding R. C., Luecke D., Edmiston C., Gerhardt P. Synergism of penicillin and gentamicin against Listeria monocytogenes in ex vivo hemodialysis culture. J Infect Dis. 1977 Jan;135(1):51–54. doi: 10.1093/infdis/135.1.51. [DOI] [PubMed] [Google Scholar]
- Nieman R. E., Lorber B. Listeriosis in adults: a changing pattern. Report of eight cases and review of the literature, 1968-1978. Rev Infect Dis. 1980 Mar-Apr;2(2):207–227. doi: 10.1093/clinids/2.2.207. [DOI] [PubMed] [Google Scholar]
- Sande M. A., Scheld W. M. Combination antibiotic therapy of bacterial endocarditis. Ann Intern Med. 1980 Mar;92(3):390–395. doi: 10.7326/0003-4819-92-3-390. [DOI] [PubMed] [Google Scholar]
- Saravolatz L. D., Burch K. H., Madhavan T., Quinn E. L. Listerial prosthetic valve endocarditis. Successful medical therapy. JAMA. 1978 Nov 10;240(20):2186–2187. [PubMed] [Google Scholar]
- Scheld W. M., Fletcher D. D., Fink F. N., Sande M. A. Response to therapy in an experimental rabbit model of meningitis due to Listeria monocytogenes. J Infect Dis. 1979 Sep;140(3):287–294. doi: 10.1093/infdis/140.3.287. [DOI] [PubMed] [Google Scholar]
- Wiggins G. L., Albritton W. L., Feeley J. C. Antibiotic susceptibility of clinical isolates of Listeria monocytogenes. Antimicrob Agents Chemother. 1978 May;13(5):854–860. doi: 10.1128/aac.13.5.854. [DOI] [PMC free article] [PubMed] [Google Scholar]