Abstract
Moxalactam was evaluated in the therapy of lower respiratory tract infections in 40 patients. The most common organisms isolated were Streptococcus pneumoniae (37.2%) and Haemophilus influenzae (21.5%). Gram-negative enteric organisms were isolated from six patients. No patient was evaluated as a treatment failure; however, two patients died of unrelated causes either during therapy or in the immediate posttherapy period. We determined the comparative minimal inhibitory concentrations of moxalactam, cefamandole, and cephalothin for our aerobic clinical isolates. Susceptibilities of the anaerobic isolates were measured by the Kirby-Bauer method. All isolates were susceptible to moxalactam. Moxalactam was found to be highly effective in the therapy of lower respiratory tract infections.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barza M., Tally F. P., Jacobus N. V., Gorbach S. L. In vitro activity of LY127935. Antimicrob Agents Chemother. 1979 Sep;16(3):287–292. doi: 10.1128/aac.16.3.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Dorff G. J., Rytel M. W., Farmer S. G., Scanlon G. Etiologies and characteristic features of pneumonias in a municipal hospital. Am J Med Sci. 1973 Nov;266(5):349–358. doi: 10.1097/00000441-197311000-00002. [DOI] [PubMed] [Google Scholar]
- Ebright J. R., Rytel M. W. Bacterial pneumonia in the elderly. J Am Geriatr Soc. 1980 May;28(5):220–223. doi: 10.1111/j.1532-5415.1980.tb00523.x. [DOI] [PubMed] [Google Scholar]
- Fass R. J. In vitro activity of LY127935. Antimicrob Agents Chemother. 1979 Oct;16(4):503–509. doi: 10.1128/aac.16.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Findell C. M., Sherris J. C. Susceptibility of Enterobacter to cefamandole: evidence for a high mutation rate to resistance. Antimicrob Agents Chemother. 1976 Jun;9(6):970–974. doi: 10.1128/aac.9.6.970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glew R. H., Moellering R. C., Jr, Kunz L. J. Infections with Acinetobacter calcoaceticus (Herellea vaginicola): clinical and laboratory studies. Medicine (Baltimore) 1977 Mar;56(2):79–97. doi: 10.1097/00005792-197703000-00001. [DOI] [PubMed] [Google Scholar]
- Trager G. M., White G. W., Zimelis V. M., Panwalker A. P. LY-127935: a novel beta-lactam antibiotic with unusual antibacterial activity. Antimicrob Agents Chemother. 1979 Sep;16(3):297–300. doi: 10.1128/aac.16.3.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace R. J., Jr, Musher D. M., Martin R. R. Hemophilus influenzae pneumonia in adults. Am J Med. 1978 Jan;64(1):87–93. doi: 10.1016/0002-9343(78)90182-1. [DOI] [PubMed] [Google Scholar]