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. 1981 May;19(5):927–929. doi: 10.1128/aac.19.5.927

Selective Inhibition of Herpesvirus Deoxyribonucleic Acid Synthesis by Acycloguanosine, 2′-Fluoro-5-Iodo-Aracytosine, and (E)-5-(2-Bromovinyl)-2′-Deoxyuridine

A Larsson 1, B Öberg 1
PMCID: PMC181545  PMID: 6271053

Abstract

The selectivity of inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2′-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2′-deoxyuridine was determined by isopycnic banding of 32P-labeled deoxyribonucleic acid from herpesvirus-infected and uninfected cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. De Clercq E., Descamps J., De Somer P., Barr P. J., Jones A. S., Walker R. T. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947–2951. doi: 10.1073/pnas.76.6.2947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Drach J. C., Shipman C., Jr The selective inhibition of viral DNA synthesis by chemotherapeutic agents: an indicator of clinical usefulness? Ann N Y Acad Sci. 1977 Mar 4;284:396–409. doi: 10.1111/j.1749-6632.1977.tb21976.x. [DOI] [PubMed] [Google Scholar]
  3. Elion G. B., Furman P. A., Fyfe J. A., de Miranda P., Beauchamp L., Schaeffer H. J. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716–5720. doi: 10.1073/pnas.74.12.5716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eriksson B., Oberg B. Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate. Antimicrob Agents Chemother. 1979 Jun;15(6):758–762. doi: 10.1128/aac.15.6.758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Furman P. A., St Clair M. H., Fyfe J. A., Rideout J. L., Keller P. M., Elion G. B. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol. 1979 Oct;32(1):72–77. doi: 10.1128/jvi.32.1.72-77.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Helgstrand E., Oberg B. Enzymatic targets in virus chemotherapy. Antibiot Chemother (1971) 1980;27:22–69. doi: 10.1159/000385389. [DOI] [PubMed] [Google Scholar]
  7. Lopez C., Watanabe K. A., Fox J. J. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803–806. doi: 10.1128/aac.17.5.803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Prusoff W. H., Ward D. C. Nucleoside analogs with antiviral activity. Biochem Pharmacol. 1976 Jun 1;25(11):1233–1239. doi: 10.1016/0006-2952(76)90083-6. [DOI] [PubMed] [Google Scholar]
  9. Schaeffer H. J., Beauchamp L., de Miranda P., Elion G. B., Bauer D. J., Collins P. 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature. 1978 Apr 13;272(5654):583–585. doi: 10.1038/272583a0. [DOI] [PubMed] [Google Scholar]
  10. Watanabe K. A., Reichman U., Hirota K., Lopez C., Fox J. J. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. J Med Chem. 1979 Jan;22(1):21–24. doi: 10.1021/jm00187a005. [DOI] [PubMed] [Google Scholar]

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