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. 1981 Aug;20(2):231–234. doi: 10.1128/aac.20.2.231

Biliary excretion of moxalactam.

O V Martinez, J U Levi, A Livingstone, T I Malinin, R Zeppa, D Hutson, N Einhorn
PMCID: PMC181668  PMID: 6456690

Abstract

The biliary excretion of moxalactam was studied in 11 postsurgery patients who had indwelling T-tubes inserted in their common bile ducts. Peak levels of moxalactam in the bile reached mean levels of 33.7 +/- 11.1 and 173.7 +/- 67.0 micrograms/ml 2 h after intravenous administration of a single 500- or 2,000-mg dose, respectively. In 5 of the 10 patients given the 2,000-mg dose, peak moxalactam concentrations in the bile were 2 to 12 times higher than simultaneous serum levels, but considerable variation in the biliary excretion of moxalactam was observed among the individual patients.

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Selected References

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