Abstract
Moxalactam, a potent new beta-lactam antibiotic with a relatively wide spectrum of activity against facultative and anaerobic gram-negative bacilli, was evaluated in vitro and in 28 patients with a variety of severe infections with moxalactam-susceptible organisms (minimum inhibitory concentration less than or equal to 31 microgram/ml). Although therapy was successful in most of these patients, caution is suggested because of the development of resistance on therapy in one patient, persistence of Bacteroides fragilis endocarditis in another, and for certain organisms, a significant inoculum effect on the minimum inhibitory concentration and minimum bactericidal concentration of moxalactam.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronoff G. R., Sloan R. S., Mong S. A., Luft F. C., Kleit S. A. Moxalactam pharmacokinetics during hemodialysis. Antimicrob Agents Chemother. 1981 Apr;19(4):575–577. doi: 10.1128/aac.19.4.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gibbs R. S., Blanco J. D., Castaneda Y. S., St Clair P. J. Therapy of obstetrical infections with moxalactam. Antimicrob Agents Chemother. 1980 Jun;17(6):1004–1007. doi: 10.1128/aac.17.6.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lerner P. I., Lubin A. Letter: Coagulopathy with cefazolin in uremia. N Engl J Med. 1974 Jun 6;290(23):1324–1324. doi: 10.1056/NEJM197406062902317. [DOI] [PubMed] [Google Scholar]
- Natelson E. A., Brown C. H., 3rd, Bradshaw M. W., Alfrey C. P., Jr, Williams T. W., Jr Influence of cephalosporin antibiotics on blood coagulation and platelet function. Antimicrob Agents Chemother. 1976 Jan;9(1):91–93. doi: 10.1128/aac.9.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Natelson E. A., Siebert W. T., Williams T. W., Bradshaw M. W. Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function. Am J Med Sci. 1979 Nov-Dec;278(3):217–221. doi: 10.1097/00000441-197911000-00005. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Aswapokee N., Fu K. P., Aswapokee P. Antibacterial activity of a new 1-oxa cephalosporin compared with that of other beta-lactam compounds. Antimicrob Agents Chemother. 1979 Aug;16(2):141–149. doi: 10.1128/aac.16.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parsons J. N., Romano J. M., Levison M. E. Pharmacology of a new 1-oxa-beta-lactam (LY127935) in normal volunteers. Antimicrob Agents Chemother. 1980 Feb;17(2):226–228. doi: 10.1128/aac.17.2.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wise R., Andrews J. M., Bedford K. A. LY127935, a novel oxa-beta-lactam: an in vitro comparison with other beta-lactam antibiotics. Antimicrob Agents Chemother. 1979 Sep;16(3):341–345. doi: 10.1128/aac.16.3.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu V. L. Enterococcal superinfection and colonization after therapy with moxalactam, a new broad-spectrum antibiotic. Ann Intern Med. 1981 Jun;94(6):784–785. doi: 10.7326/0003-4819-94-6-784. [DOI] [PubMed] [Google Scholar]