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. 1982 Jan;21(1):1–4. doi: 10.1128/aac.21.1.1

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.

V M Millet, M Dreisbach, Y J Bryson
PMCID: PMC181819  PMID: 7044294

Abstract

A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment. Subjective side effects in recipients of amantadine, rimantadine, and chlorpheniramine were comparable and minimal. Side effects appeared to be enhanced in subjects receiving both amantadine and chlorpheniramine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryson Y. J., Monahan C., Pollack M., Shields W. D. A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis. J Infect Dis. 1980 May;141(5):543–547. doi: 10.1093/infdis/141.5.543. [DOI] [PubMed] [Google Scholar]
  2. Casey D. E. Amantadine intoxication reversed by physostigmine. N Engl J Med. 1978 Mar 2;298(9):516–516. doi: 10.1056/nejm197803022980919. [DOI] [PubMed] [Google Scholar]
  3. Hayden F. G., Gwaltney J. M., Jr, Van de Castle R. L., Adams K. F., Giordani B. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother. 1981 Feb;19(2):226–233. doi: 10.1128/aac.19.2.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jackson G. G., Stanley E. D. Prevention and control of influenza by chemoprophylaxis and chemotherapy. Prospects from examination of recent experience. JAMA. 1976 Jun 21;235(25):2739–2742. [PubMed] [Google Scholar]
  5. Keogh B. K., Margolis J. S. A component analysis of attentional problems of educationally handicapped boys. J Abnorm Child Psychol. 1976;4(4):349–359. doi: 10.1007/BF00922532. [DOI] [PubMed] [Google Scholar]
  6. LaMontagne J. R., Galasso G. J. From the National Institutes of Health. Report of a workshop on clinical studies of the efficacy of amantadine and rimantadine against influenza vireus. J Infect Dis. 1978 Dec;138(6):928–931. doi: 10.1093/infdis/138.6.928. [DOI] [PubMed] [Google Scholar]
  7. Monto A. S., Gunn R. A., Bandyk M. G., King C. L. Prevention of Russian influenza by amantadine. JAMA. 1979 Mar 9;241(10):1003–1007. [PubMed] [Google Scholar]
  8. Rabinovich S., Baldini J. T., Bannister R. Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak. Am J Med Sci. 1969 May;257(5):328–335. doi: 10.1097/00000441-196905000-00005. [DOI] [PubMed] [Google Scholar]
  9. Roth W. T., Tinklenberg J. R., Whitaker C. A., Darley C. F., Kopell B. S., Hollister L. E. The effect of marihuana on tracking task performance. Psychopharmacologia. 1973;33(3):259–265. doi: 10.1007/BF00423060. [DOI] [PubMed] [Google Scholar]
  10. Smorodintsev A. A., Zlydnikov D. M., Kiseleva A. M., Romanov J. A., Kazantsev A. P., Rumovsky V. I. Evaluation of amantadine in artificially induced A2 and B influenza. JAMA. 1970 Aug 31;213(9):1448–1454. [PubMed] [Google Scholar]
  11. Wingfield W. L., Pollack D., Grunert R. R. Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man. N Engl J Med. 1969 Sep 11;281(11):579–584. doi: 10.1056/NEJM196909112811102. [DOI] [PubMed] [Google Scholar]

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