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. 1978 Apr 22;118(8):907-10, 913.

Chronic renal failure in children.

J G Mongeau, P Robitaille, M M Grall
PMCID: PMC1818236  PMID: 647561

Abstract

Seventy-seven children with chronic renal failure were examined at one hospital in the province of Quebec between 1970 and 1975; this represents an incidence of 2.5 per million population per year. The entities responsible for chronic renal failure were urinary tract malformation (in 36%), chronic glomerulonephritis (in 22%), congenital renal parenchymal malformation (in 21%) and hereditary nephropathy (in 13%). The evolution of chronic renal failure in children with either vesicoureteral reflux or a posterior urethral valve seemed to be related more to the initial severity of the disease than to the age at the time of diagnosis. Hence any screening program designed to detect kidney disease in schoolchildren would not prevent chronic renal failure, since at that age renal parenchymal damage seems to be irreversible. The manner in which chronic glomerulonephritis evolved depended on whether the nephrotic syndrome was present and on the type of histologic lesion. Children with congenital renal hypoplasia or dysplasia often presented with seizures due to hypertensive encephalopathy without obvious symptoms or signs of pre-existing renal disease. Among patients with familial nephropathy many of those with cystinosis underwent successful renal transplantation early in life.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aperia A., Broberger O., Ericsson N. O., Wikstad I. Effect of vesicoureteral reflux on renal function in children with recurrent urinary tract infection.s. Kidney Int. 1976 May;9(5):418–423. doi: 10.1038/ki.1976.51. [DOI] [PubMed] [Google Scholar]
  2. Barratt T. M. Renal failure in the first year of life. Br Med Bull. 1971 May;27(2):115–121. doi: 10.1093/oxfordjournals.bmb.a070833. [DOI] [PubMed] [Google Scholar]
  3. Couser W. G., Idelson B. A., Stilmant M. M., Migdal S. D., Davis R. C. Successful renal transplantation in focal glomerular sclerosis: report of two cases. Clin Nephrol. 1975 Aug;4(2):62–67. [PubMed] [Google Scholar]
  4. Habib R., Broyer M., Benmaiz H. Chronic renal failure in children. Causes, rate of deterioration and survival data. Nephron. 1973;11(2):209–220. doi: 10.1159/000180231. [DOI] [PubMed] [Google Scholar]
  5. Hayslett J. P., Krassner L. S., Bensch K. G., Kashgarian M., Epstein F. H. Progression of "lipoid nephrosis" to renal insufficiency. N Engl J Med. 1969 Jul 24;281(4):181–187. doi: 10.1056/NEJM196907242810402. [DOI] [PubMed] [Google Scholar]
  6. Mahoney C. P., Striker G. E., Fetterman G. H., Hickman R. O., Schneider J. A., Marchioro T. L. Renal transplantation in childhood cystinosis: effects of the metabolic disease and renal allografts on each other. Birth Defects Orig Artic Ser. 1973 Mar;9(2):141–148. [PubMed] [Google Scholar]
  7. Pendreigh D. M., Howitt L. F., Macdougall A. J., Robson J. S., Heasman M. A., Kennedy A. C., MacLeod M., Stewart W. K. Survey of chronic renal failure in Scotland. Lancet. 1972 Feb 5;1(7745):304–307. doi: 10.1016/s0140-6736(72)90304-2. [DOI] [PubMed] [Google Scholar]
  8. Salvatierra O., Jr, Kountz S. L., Belzer F. O. Primary vesicoureteral reflux and end-stage renal disease. JAMA. 1973 Dec 17;226(12):1454–1456. [PubMed] [Google Scholar]
  9. Schärer K., Chantler C., Brunner F. P., Gurland H. J., Jacobs C., Parsons F. M., Seyffart G., Wing A. J. Dialysis and renal transplantation of children in Europe, 1974. Acta Paediatr Scand. 1976 Nov;65(6):657–662. doi: 10.1111/j.1651-2227.1976.tb17998.x. [DOI] [PubMed] [Google Scholar]
  10. Turner D. R., Cameron J. S., Bewick M., Sharpstone P., Melcher D., Ogg C. S., Evans D. J., Trafford A. J., Leibowitz Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense "deposits": recurrence of disease. Kidney Int. 1976 May;9(5):439–448. doi: 10.1038/ki.1976.54. [DOI] [PubMed] [Google Scholar]
  11. West C. D. Membranoproliferative hypocomplementemic glomerulonephritis. Nephron. 1973;11(2):134–146. doi: 10.1159/000180226. [DOI] [PubMed] [Google Scholar]
  12. Wilson R. E. Transplantation in patients with unusual causes of renal failure. Clin Nephrol. 1976 Feb;5(2):51–53. [PubMed] [Google Scholar]

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