Abstract
Persistent infection of the gastrointestinal tract of CFW mice with Candida albicans was produced by the oral-intragastric inoculation of 6-day-old infants. Other intraabdominal organs (liver, kidneys, and spleen) were usually free of the organism in survivors at 20 days of age. However, all survivors retained high levels of the organism in the stomach and intestinal tract at 30 days of age. The possible utility of these persisting C. albicans infections of the gastrointestinal tract for the study of the efficacy of short-term antifungal therapy was studied. Drug treatment was initiated for a 2-week period when the survivors were 15 to 19 days old. Some representative antifungal agents in current use (i.e., amphotericin B, 5-fluorocytosine, and miconazole) effected significant reductions in the numbers of C. albicans in homogenates of gastrointestinal organs.
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Selected References
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- Field L. H., Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Persistence and spread of Candida albicans after intragastric inoculation of infant mice. Infect Immun. 1981 Feb;31(2):783–791. doi: 10.1128/iai.31.2.783-791.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guentzel M. N., Berry L. J. Protection of suckling mice from experimental cholera by maternal immunization: comparison of the efficacy of whole-cell, ribosomal-derived, and enterotoxin immunogens. Infect Immun. 1974 Jul;10(1):167–172. doi: 10.1128/iai.10.1.167-172.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guentzel M. N., Herrera C. Effects of compromising agents on candidosis in mice with persistent infections initiated in infancy. Infect Immun. 1982 Jan;35(1):222–228. doi: 10.1128/iai.35.1.222-228.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Helstrom P. B., Balish E. Effect of oral tetracycline, the microbial flora, and the athymic state on gastrointestinal colonization and infection of BALB/c mice with Candida albicans. Infect Immun. 1979 Mar;23(3):764–774. doi: 10.1128/iai.23.3.764-774.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge. Infect Immun. 1979 Aug;25(2):702–707. doi: 10.1128/iai.25.2.702-707.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turner J. R., Butler T. F., Johnson M. E., Gordee R. S. Colonization of the intestinal tract of conventional mice with Candida albicans and treatment with antifungal agents. Antimicrob Agents Chemother. 1976 May;9(5):787–792. doi: 10.1128/aac.9.5.787. [DOI] [PMC free article] [PubMed] [Google Scholar]