Abstract
The in vitro interaction of moxalactam and mecillinam against multi-drug-resistant gram-negative enteric bacilli was studied by checkerboard microdilution susceptibility tests and by killing curve kinetics. Against Enterobacteriaceae, the combination was unpredictable; the frequencies of synergy, indifference, and antagonism were 11, 76, and 13%, respectively. Against Pseudomonas sp., the two drugs were consistently indifferent. Overall, the combination of moxalactam and mecillinam was no more active than moxalactam alone.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Acar J. F., Sabath L. D., Ruch P. A. Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins. J Clin Invest. 1975 Mar;55(3):446–453. doi: 10.1172/JCI107950. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fass R. J. Activity of mecillinam alone and in combination with other beta-lactam antibiotics. Antimicrob Agents Chemother. 1980 Dec;18(6):906–912. doi: 10.1128/aac.18.6.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fass R. J., Barnishan J. In vitro susceptibilities of nonfermentative gram-negative bacilli other than Pseudomonas aeruginosa to 32 antimicrobial agents. Rev Infect Dis. 1980 Nov-Dec;2(6):841–853. doi: 10.1093/clinids/2.6.841. [DOI] [PubMed] [Google Scholar]
- Fass R. J. In vitro activities of beta-lactam and aminoglycoside antibiotics. A comparative study of 20 parenterally administered drugs. Arch Intern Med. 1980 Jun;140(6):763–768. [PubMed] [Google Scholar]
- Fass R. J. In vitro activity of LY127935. Antimicrob Agents Chemother. 1979 Oct;16(4):503–509. doi: 10.1128/aac.16.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Komatsu Y., Nishikawa T. Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother. 1980 Mar;17(3):316–321. doi: 10.1128/aac.17.3.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuck N. A., Testa R. T., Forbes M. In vitro and in vivo antibacterial effects of combinations of beta-lactam antibiotics. Antimicrob Agents Chemother. 1981 Apr;19(4):634–638. doi: 10.1128/aac.19.4.634. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu J. C. Synergy of mecillinam, a beta-amidinopenicillanic acid derivative, combined with beta-lactam antibiotics. Antimicrob Agents Chemother. 1976 Sep;10(3):535–542. doi: 10.1128/aac.10.3.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanders C. C., Sanders W. E., Jr Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases. Antimicrob Agents Chemother. 1979 Jun;15(6):792–797. doi: 10.1128/aac.15.6.792. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spratt B. G. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999–3003. doi: 10.1073/pnas.72.8.2999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tybring L., Melchior N. H. Mecillinam (FL 1060), a 6beta-amidinopenicillanic acid derivative: bactericidal action and synergy in vitro. Antimicrob Agents Chemother. 1975 Sep;8(3):271–276. doi: 10.1128/aac.8.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinner S. H., Provonchee R. B., Elias K. S., Peter G. Effect of clindamycin on the in vitro activity of amikacin and gentamicin against gram-negative bacilli. Antimicrob Agents Chemother. 1976 Apr;9(4):661–664. doi: 10.1128/aac.9.4.661. [DOI] [PMC free article] [PubMed] [Google Scholar]