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. 1982 Feb;21(2):195–200. doi: 10.1128/aac.21.2.195

Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam.

J Berenguer, M A de Pedro, D Vázquez
PMCID: PMC181858  PMID: 6280596

Abstract

Nocardicin A and mecillinam are two beta-lactam antibiotics with poor bacteriolytic activity against Escherichia coli. However, the combined use of these drugs resulted in the induction of a fast lytic response in E. coli cells. For this cooperative effect to take place, the formation of a complex between penicillin-binding protein 2 and mecillinam is apparently necessary. This suggests that penicillin-binding protein 2 might be actively involved in the response of E. coli to bacteriolytic beta-lactam antibiotics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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