Abstract
Three infants with congenital rubella syndrome were given human leukocyte (alpha) interferon at doses of 2 x 10(5) to 7 X 10(5) U/kg per day for 10 days. A transient decrease in pharyngeal virus excretion was observed with treatment. No significant side effects were associated with the administration of human leukocyte interferon to these infants.
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- Cooper L. Z., Krugman S. Clinical manifestations of postnatal and congenital rubella. Arch Ophthalmol. 1967 Apr;77(4):434–439. doi: 10.1001/archopht.1967.00980020436004. [DOI] [PubMed] [Google Scholar]
- Desmyter J., Rawls W. E., Melnick J. L., Yow M. D., Barrett F. F. Interferon in congenital rubella: response to live attenuated measles vaccine. J Immunol. 1967 Oct;99(4):771–777. [PubMed] [Google Scholar]
- Dudgeon J. A. Congenital rubella. J Pediatr. 1975 Dec;87(6 Pt 2):1078–1086. doi: 10.1016/s0022-3476(75)80119-3. [DOI] [PubMed] [Google Scholar]
- Larsson A., Forsgren M., Hård af Segerstad S., Strander H., Cantell K. Administration of interferon to an infant with congenital rubella syndrome involving persistent viremia and cutaneous vasculitis. Acta Paediatr Scand. 1976 Jan;65(1):105–110. doi: 10.1111/j.1651-2227.1976.tb04415.x. [DOI] [PubMed] [Google Scholar]
- Schmidt N. J., Dennis J., Lennette E. H. Comparison of immunofluorescence and immunoperoxidase staining for identification of rubella virus isolates. J Clin Microbiol. 1978 Jun;7(6):576–583. doi: 10.1128/jcm.7.6.576-583.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wong K. T., Robinson W. S., Merigan T. C. Inhibition of rubella virus-specific RNA synthesis by interferon. Proc Soc Exp Biol Med. 1971 Feb;136(2):615–618. doi: 10.3181/00379727-136-35324. [DOI] [PubMed] [Google Scholar]