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. 1978 May 6;118(9):1097, 1100-2, 1107-8.

Minor tranquillizers in somatic disorders.

C Krogh, W M McLean, Y D LaPierre
PMCID: PMC1818696  PMID: 25708

Abstract

Conclusive evidence of improved outcome due to adjunctive anxiolytic therapy in some somatic conditions is lacking. However, such therapy may facilitate patient management without being "curative". The resulting improved feeling of well-being may be of value in the management of gastrointestinal disorders, migraine and myocardial infarction. Negative effects may be observed in acute respiratory conditions, especially during acute exacerbations of chronic conditions, with the administration of benzodiazepines; hence they should be used with caution. The use of these agents in treating persons with hypertension seems to be of no value and may even be detrimental. Careful evaluation of each case is desirable, and treatment should be planned with its termination in mind.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abel R. M., Reis R. L. Intravenous diazepam for sedation following cardiac operations: clinical and hemodynamic assessments. Anesth Analg. 1971 Mar-Apr;50(2):244–248. [PubMed] [Google Scholar]
  2. Alanko K., Lahdensuo A., Mattila M. J. Bronchodilator effect of oral salbutamol and an ephedrine+theophylline+hydroxyzine combination in asthmatic out-patients. Scand J Respir Dis. 1974;55(6):340–350. [PubMed] [Google Scholar]
  3. Bierman C. W., Pierson W. E., Shapiro G. G. The pharmacological assessment of single drugs and drug combinations in exercise-induced asthma. Pediatrics. 1975 Nov;56(5 PT-2):919–922. [PubMed] [Google Scholar]
  4. Blackwell B. Psychotropic drugs in use today. The role of diazepam in medical practice. JAMA. 1973 Sep 24;225(13):1637–1641. [PubMed] [Google Scholar]
  5. Blumberg M. Z., Young S. Diazepam-associated asthma. Pediatrics. 1974 Dec;54(6):811–812. [PubMed] [Google Scholar]
  6. Catchlove R. F., Kafer E. R. The effects of diazepam on respiration in patients with obstructive pulmonary disease. Anesthesiology. 1971 Jan;34(1):14–18. doi: 10.1097/00000542-197101000-00006. [DOI] [PubMed] [Google Scholar]
  7. Chodosh S., Doraiswami S. An evaluation of theophylline/ephedrine with and without hydroxyzine in asthma. Curr Ther Res Clin Exp. 1975 Dec;18(6):773–784. [PubMed] [Google Scholar]
  8. Clark T. J., Collins J. V., Tong D. Respiratory depression caused by nitrazepam in patients with respiratory failure. Lancet. 1971 Oct 2;2(7727):737–738. doi: 10.1016/s0140-6736(71)92105-2. [DOI] [PubMed] [Google Scholar]
  9. Daniell H. B. Cardiovascular effects of diazepam and chlordiazepoxide. Eur J Pharmacol. 1975 May;32(1):58–65. doi: 10.1016/0014-2999(75)90323-4. [DOI] [PubMed] [Google Scholar]
  10. Denaut M., Yernault J. C., De Coster A. Double-blind comparison of the respiratory effects of parenteral lorazepam and diazepam in patients with chronic obstructive lung disease. Curr Med Res Opin. 1974;2(10):611–615. doi: 10.1185/03007997409111871. [DOI] [PubMed] [Google Scholar]
  11. Deutsch E. M. Relief of anxiety and related emotions in patients with gastrointestinal disorders. A double-blind controlled study. Am J Dig Dis. 1971 Dec;16(12):1091–1094. doi: 10.1007/BF02235166. [DOI] [PubMed] [Google Scholar]
  12. Forssell G., Nordlander R., Nyquist O., Orinius E. Diazepam in cardioversion. Acta Med Scand. 1975 Apr;197(4):255–256. doi: 10.1111/j.0954-6820.1975.tb04912.x. [DOI] [PubMed] [Google Scholar]
  13. Furtado J. D. Lorazepam in gastrointestinal disorders with anxiety overlay. Psychosomatics. 1976;17(1):32–34. doi: 10.1016/S0033-3182(76)71169-1. [DOI] [PubMed] [Google Scholar]
  14. Gedeon A., Várkonyi S. Symptomatic treatment of myocardial infarction and acute psychosyndrome with Seduxen injections. Ther Hung. 1973;21(1):41–42. [PubMed] [Google Scholar]
  15. Greenblatt D. J., Shader R. I. Drug therapy. Benzodiazepines (first of two parts). N Engl J Med. 1974 Nov 7;291(19):1011–1015. doi: 10.1056/NEJM197411072911906. [DOI] [PubMed] [Google Scholar]
  16. Greenblatt D. J., Shader R. I., Lofgren S. Rational psycho-pharmacology for patients with medical diseases. Annu Rev Med. 1976;27:407–420. doi: 10.1146/annurev.me.27.020176.002203. [DOI] [PubMed] [Google Scholar]
  17. Grice A. S. Letter: SIDS--is this the answer? Med J Aust. 1975 Nov 22;2(21):809–809. [PubMed] [Google Scholar]
  18. Hackett T. P., Cassem N. H. Reduction of anxiety in the coronary-care unit. A controlled double-blind comparison of chlordiazepoxide and amobarbital. Curr Ther Res Clin Exp. 1972 Oct;14(10):649–656. [PubMed] [Google Scholar]
  19. Huch R., Huch A. Letter: Respiratory depression after tranquillisers. Lancet. 1974 Nov 23;2(7891):1267–1267. doi: 10.1016/s0140-6736(74)90783-1. [DOI] [PubMed] [Google Scholar]
  20. Kanto J. Plasma concentrations of diazepam and its metabolites after peroral, intramuscular, and rectal administration. Correlation between plasma concentration and sedatory effect of diazepam. Int J Clin Pharmacol Biopharm. 1975 Dec;12(4):427–432. [PubMed] [Google Scholar]
  21. Kasich A. M. Chlorazepate dipotassium in the treatment of anxiety associated with chronic gastrointestinal disease. Curr Ther Res Clin Exp. 1973 Mar;15(3):83–91. [PubMed] [Google Scholar]
  22. Kasich A. M. Lorazepam in the management of anxiety associated with chronic gastrointestinal disease: a double-blind study. Curr Ther Res Clin Exp. 1976 Mar;19(3):292–306. [PubMed] [Google Scholar]
  23. Kellett J. M. Letter: The benzodiazepine bonanza. Lancet. 1974 Oct 19;2(7886):964–964. doi: 10.1016/s0140-6736(74)91183-0. [DOI] [PubMed] [Google Scholar]
  24. Kronenberg R. S., Cosio M. G., Stevenson J. E., Drage C. W. Letter: The use of oral diazepam in patients with obstructive lung disease and hypercapnia. Ann Intern Med. 1975 Jul;83(1):83–84. doi: 10.7326/0003-4819-83-1-83. [DOI] [PubMed] [Google Scholar]
  25. Melsom M., Andreassen P., Melsom H., Hansen T., Grendahl H., Hillestad L. K. Diazepam in acute myocardial infarction. Clinical effects and effects on catecholamines, free fatty acids, and cortisol. Br Heart J. 1976 Aug;38(8):804–810. doi: 10.1136/hrt.38.8.804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Merlo L., Noseda V., Ferrini R., Miragoli G., Marchetti G. Effect of camazepam (SB-5833), a new antianxious drug, on cardiac contractility and coronary hemodynamics. Arzneimittelforschung. 1974 Nov;24(11):1759–1762. [PubMed] [Google Scholar]
  27. Model D. G., Berry D. J. Effects of chlordiazepoxide in respiratory failure due to chronic bronchitis. Lancet. 1974 Oct 12;2(7885):869–870. doi: 10.1016/s0140-6736(74)91203-3. [DOI] [PubMed] [Google Scholar]
  28. Model D. G. Nitrazepam induced respiratory depression in chronic obstructive lung disease. Br J Dis Chest. 1973 Apr;67(2):128–130. doi: 10.1016/0007-0971(73)90042-9. [DOI] [PubMed] [Google Scholar]
  29. Okasha A., Ghaleb H. A., Sadek A. A double blind trial for the clinical management of psychogenic headache. Br J Psychiatry. 1973 Feb;122(567):181–183. doi: 10.1192/bjp.122.2.181. [DOI] [PubMed] [Google Scholar]
  30. Parkes J. D. Diseases of the central nervous system. Relief of pain: headache, facial neuralgia, migraine, and phantom limb. Br Med J. 1975 Oct 11;4(5988):90–92. doi: 10.1136/bmj.4.5988.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Rao S., Sherbaniuk R. W., Prasad K., Lee S. J., Sproule B. J. Cardiopulmonary effects of diazepam. Clin Pharmacol Ther. 1973 Mar-Apr;14(2):182–189. doi: 10.1002/cpt1973142182. [DOI] [PubMed] [Google Scholar]
  32. Roberts D. M., Oldrey T. B. The effect of diazepam on pentagastrin-stimulated and nocturnal (sleeping) gastric secretion in man. Am J Gastroenterol. 1975 May;63(5):396–399. [PubMed] [Google Scholar]
  33. SANTOS I. M., UNGER L. Hydroxyzine (atarax) in allergic diseases. Ann Allergy. 1960 Feb;18:172–178. [PubMed] [Google Scholar]
  34. SPANKUS W. H. ROLE OF A NEW PSYCHOTROPIC DRUG IN SOMATIC DISORDERS. Psychosomatics. 1964 May-Jun;5:153–156. doi: 10.1016/s0033-3182(64)72434-6. [DOI] [PubMed] [Google Scholar]
  35. Skupin G., Franzke H. G. Die Stellung von Dikalium-chlorazepat (Tranxilium) in der Therapie psychovegetativer Syndrome. Med Klin. 1975 Aug 1;70(31):1279–1283. [PubMed] [Google Scholar]
  36. Speight T. M., Avery G. S. Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches. Drugs. 1972;3(3):159–203. doi: 10.2165/00003495-197203030-00002. [DOI] [PubMed] [Google Scholar]
  37. Stacher G., Stärker D. Inhibitory effect of bromazepam on insulin-stimulated gastric acid secretion in man. Am J Dig Dis. 1975 Feb;20(2):156–161. doi: 10.1007/BF01072342. [DOI] [PubMed] [Google Scholar]
  38. Swanson D. A. Benzodiazepines in psychiatry. S Afr Med J. 1975 Oct 18;49(44):1829–1834. [PubMed] [Google Scholar]
  39. VOEGTLIN W. L. MANAGEMENT OF FUNCTIONAL GASTROINTESTINAL DISORDERS WITH DIAZEPAM. Appl Ther. 1964 Oct;6:801–805. [PubMed] [Google Scholar]
  40. Winstead D. K., Lawson T., Abbott D. Diazepam use in military sick call. Mil Med. 1976 Mar;141(3):180–181. [PubMed] [Google Scholar]
  41. Zsigmond E. K., Shively J. G., Flynn K. Diazepam and meperidine on arterial blood gases in patients with chronic obstructive pulmonary disease. J Clin Pharmacol. 1975 May-Jun;15(5-6):464–469. doi: 10.1002/j.1552-4604.1975.tb02370.x. [DOI] [PubMed] [Google Scholar]

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