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. 1978 Oct 7;119(7):701–704.

Hemoglobinopathies in a hospital population in Vancouver.

G R Gray, R B Marion
PMCID: PMC1818787  PMID: 709469

Abstract

A number of varieties of thalassemia were found to be common in the Vancouver area and in other parts of British Columbia. Of 3117 patients whose blood samples were studied by hemoglobin electrophoresis at the Vancouver General Hospital between Jan 1, 1965 and June 30,1977, 813 had the beta-thalassemia trait, 18 had homozygous beta-thalassemia, 97 had alpha-thalassemia trait, 24 had hemoglobin H disease and 14 had miscellaneous variants. Eight patients had interactions of beta-thalassemia with hemoglobin S,C, D, O arab or Vancouver, and one patient had alpha thalassemia associated with hemoglobin Constant Spring. Twelve other variants were noted. They included hemoglobins B2, E, Q, GHsi Tsou, J Bangkok, British Columbia, KOLN, Lepore, Rampa, Tacoma, St. Claude and an unidentified alpha-chain variant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackwell R. Q., Shih T. B., Wang C. L., Liu C. S. Hemoglobin G Hsi-Tsou: 79 Asp to Gly. Biochim Biophys Acta. 1972 Jan 26;257(1):49–53. doi: 10.1016/0005-2795(72)90253-x. [DOI] [PubMed] [Google Scholar]
  2. Boehme W. M., Piira T. A., Kurnick J. E., Bethlenfalvay N. C. Acquired hemoglobin H in refractor sideroblastic anemia. A preleukemic marker. Arch Intern Med. 1978 Apr;138(4):603–606. [PubMed] [Google Scholar]
  3. Brimhall B., Jones R. T., Baur E. W., Motulsky A. G. Structural characterization of hemoglobin Tacoma. Biochemistry. 1969 May;8(5):2125–2129. doi: 10.1021/bi00833a051. [DOI] [PubMed] [Google Scholar]
  4. Carrell R. W., Lehmann H., Hutchison H. E. Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature. 1966 May 28;210(5039):915–916. doi: 10.1038/210915a0. [DOI] [PubMed] [Google Scholar]
  5. Gray G. R., Marion R. B. Thalassemia and G-6-PD deficiency in Chinese-Canadians: admission screening of a hospital population. Can Med Assoc J. 1971 Aug 7;105(3):283–286. [PMC free article] [PubMed] [Google Scholar]
  6. Gray G. R., Towell M. E., Wright V. J., Hardwick D. F. Thalassemic hydrops fetalis in two Chinese-Canadian families. Can Med Assoc J. 1972 Dec 23;107(12):1186–1190. [PMC free article] [PubMed] [Google Scholar]
  7. Jones R. T., Brimhall B., Gray G. Hemoglobin British Columbia (alpha2beta2 101(G3)Glu replaced by Lys). A new variant with high oxygen affinity. Hemoglobin. 1976;1(2):171–182. doi: 10.3109/03630267608991678. [DOI] [PubMed] [Google Scholar]
  8. Jones R. T., Brimhall B., Pootrakul S., Gray G. Hemoglobin Vancouver [alpha2beta2(73)(E17) Asp replaced by Tyr]: its structure and function. J Mol Evol. 1976 Dec 31;9(1):37–44. doi: 10.1007/BF01796121. [DOI] [PubMed] [Google Scholar]
  9. Lorkin P. A., Charlesworth D., Lehmann H., Rahbar S., Tuchinda S., Eng L. I. Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine. Br J Haematol. 1970 Jul;19(1):117–125. doi: 10.1111/j.1365-2141.1970.tb01607.x. [DOI] [PubMed] [Google Scholar]
  10. Milner P. F., Clegg J. B., Weatherall D. J. Haemoglobin-H disease due to a unique haemoglobin variant with an elongated alpha-chain. Lancet. 1971 Apr 10;1(7702):729–732. doi: 10.1016/s0140-6736(71)91992-1. [DOI] [PubMed] [Google Scholar]
  11. Pootrakul S., Gray G. R., Dixon G. H. Hemoglobin J Bangkok in a Chinese Canadian newborn. Can J Biochem. 1970 Dec;48(12):1370–1376. doi: 10.1139/o70-212. [DOI] [PubMed] [Google Scholar]
  12. SIDDOO J. K., COADY C. J., MORGANDEAN L., PERRY W. H. Mediterranean anaemia in Chinese Canadians. Can Med Assoc J. 1956 Jan 15;74(2):124–130. [PMC free article] [PubMed] [Google Scholar]
  13. SIDDOO J. K., SIDDOO S. K., CHASE W. H., MORGAN-DEAN L., PERRY W. H. Thalassemia in Sikhs. Blood. 1956 Mar;11(3):197–210. [PubMed] [Google Scholar]
  14. Stamatoyannopoulos G., Fessas P., Papayannopoulou T. F-Thalassemia. A study of thirty-one families with simple heterozygotes and combinations of F-Thalassemia with A2-Thalassemia. Am J Med. 1969 Aug;47(2):194–208. doi: 10.1016/0002-9343(69)90146-6. [DOI] [PubMed] [Google Scholar]
  15. Vella F., Galbraith P., Wilson J. B., Wong S. C., Folger G. C., Huisman T. J. Hemoglobin St. Claude or alpha2-127(H10)Lys leads to Thr-beta2. Biochim Biophys Acta. 1974 Oct 9;365(2):318–322. doi: 10.1016/0005-2795(74)90003-8. [DOI] [PubMed] [Google Scholar]
  16. Weatherall D. J., Brown M. J. Juvenile chronic myeloid leukaemia. Lancet. 1970 Mar 7;1(7645):526–526. doi: 10.1016/s0140-6736(70)91615-6. [DOI] [PubMed] [Google Scholar]
  17. de Jong W. W., Bernini L. F., Meera Khan P. Haemoglobin Rampa: Alpha 95 Pro--Ser. Biochim Biophys Acta. 1971 Apr 27;236(1):197–200. doi: 10.1016/0005-2795(71)90165-6. [DOI] [PubMed] [Google Scholar]

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