Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1982 Feb;21(2):336–338. doi: 10.1128/aac.21.2.336

Occurrence of transposable trimethoprim resistance in clinical isolates of Escherichia coli devoid of self-transmissible resistance plasmids.

K J Towner, B M Venning, P A Pinn
PMCID: PMC181883  PMID: 6280601

Abstract

Fifty trimethoprim-resistant clinical isolates of Escherichia coli, devoid of self transmissible trimethoprim resistance plasmids, were examined for the presence of trimethoprim resistance transposons. Trimethoprim resistance was mobilized from 12 strains by transposition onto plasmid RP4. The trimethoprim resistance transposons isolated comprised two groups: those with and without linked streptomycin resistance.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amyes S. G., Smith J. T. Thymineless mutants and their resistance to trimethoprim. J Antimicrob Chemother. 1975 Mar;1(1):85–89. doi: 10.1093/jac/1.1.85. [DOI] [PubMed] [Google Scholar]
  2. Datta N., Hughes V. M., Nugent M. E., Richards H. Plasmids and transposons and their stability and mutability in bacteria isolated during an outbreak of hospital infection. Plasmid. 1979 Apr;2(2):182–196. doi: 10.1016/0147-619x(79)90037-4. [DOI] [PubMed] [Google Scholar]
  3. Kleckner N., Roth J., Botstein D. Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol. 1977 Oct 15;116(1):125–159. doi: 10.1016/0022-2836(77)90123-1. [DOI] [PubMed] [Google Scholar]
  4. Shapiro J. A., Sporn P. Tn402: a new transposable element determining trimethoprim resistance that inserts in bacteriophage lambda. J Bacteriol. 1977 Mar;129(3):1632–1635. doi: 10.1128/jb.129.3.1632-1635.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Sheldon R. Altered dihydrofolate reductase in fol regulatroy mutants of Escherichia coli K12. Mol Gen Genet. 1977 Mar 7;151(2):215–219. doi: 10.1007/BF00338697. [DOI] [PubMed] [Google Scholar]
  6. Sheldon R., Brenner S. Regulatory mutants of dihydrofolate reductase in Escherichia coli K12. Mol Gen Genet. 1976 Aug 10;147(1):91–97. doi: 10.1007/BF00337941. [DOI] [PubMed] [Google Scholar]
  7. Towner K. J. A clinical isolate of Escherichia coli owing its trimethoprim resistance to a chromosomally-located trimethoprim transposon. J Antimicrob Chemother. 1981 Feb;7(2):157–162. doi: 10.1093/jac/7.2.157. [DOI] [PubMed] [Google Scholar]
  8. Towner K. J., Pearson N. J., Cattell W. R., O'Grady F. Trimethoprim R plasmids isolated during long-term treatment of urinary tract infection with co-trimoxazole. J Antimicrob Chemother. 1979 Jan;5(1):45–52. doi: 10.1093/jac/5.1.45. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES