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. 1979 Jan 20;120(2):161–167.

Clinical efficacy and toxicity of netilmicin in the treatment of gram-negative infections.

F J Buckwold, A R Ronald, B Lank, L Thompson, L Fox, G K Harding
PMCID: PMC1818849  PMID: 761144

Abstract

Netilmicin, a new semisynthetic aminoglycoside antibiotic, was used to treat 41 infections in 38 patients. The outcome of four infections could not be evaluated: two patients received inadequate therapy and two did not have gram-negative infections. Clinical improvement occurred in 36 (97%) of the 37 gram-negative infections, and bacteriologic cure occurred in 30 (86%) of the 35 evaluable infections. Therapeutic serum concentrations of netilmicin were readily achieved by both intramuscular and intravenous routes. Reversible ototoxic effects occurred in 1 (3%) of 35 courses of therapy evaluated, reversible nephrotoxic effects occurred in 5 (14%) of 36 courses and mild reversible alterations in liver function occurred in 3 (19%) of 34 courses. Netilmicin appears to be effective and safe in the treatment of aerobic gram-negative infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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