Abstract
The tolerabilities of ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole (TMP-SMX) suspensions were evaluated in 263 children with otitis media. Because of watery stools, therapy was discontinued in 6 of 83 patients treated with ampicillin, in none of 89 patients treated with amoxicillin (P less than 0.01), and in 1 of 91 patients treated with TMP-SMX (P less than 0.03). Of the patients who completed the treatment courses, 13 recipients of ampicillin suffered loose or watery stools for 4 or more days, compared with 6 of the amoxicillin recipients (P less than 0.04) and 5 of the TMP-SMX recipients (P less than 0.02). Thus, ampicillin was clearly less well tolerated than either amoxicillin or TMP-SMX.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronovitx G. H. Middle ear infections in pediatric patients: treatment with amoxicillin. J Infect Dis. 1974 Jun;129(0):suppl–suppl:S186. [PubMed] [Google Scholar]
- Cooper J., Inman J. S., Dawson A. F. A comparison between co-trimoxazole and amoxycillin in the treatment of acute otitis media in general practice. Practitioner. 1976 Nov;217(1301):804–809. [PubMed] [Google Scholar]
- Halsted C., Lepow M. L., Balassanian N., Emmerich J., Wolinsky E. Otitis media. Clinical observations, microbiology, and evaluation of therapy. Am J Dis Child. 1968 May;115(5):542–551. doi: 10.1001/archpedi.1968.02100010544003. [DOI] [PubMed] [Google Scholar]
- Howie V. M., Ploussard J. H., Sloyer J. Comparison of ampicillin and amoxicillin in the treatment of otitis media in children. J Infect Dis. 1974 Jun;129(0):suppl–suppl:S184. doi: 10.1093/infdis/129.supplement_2.s181. [DOI] [PubMed] [Google Scholar]
- Jones J. D. Treatment of otitis media in pediatric practice: amoxicillin versus ampicillin. J Infect Dis. 1974 Jun;129(0):suppl–suppl:S188. doi: 10.1093/infdis/129.supplement_2.s187. [DOI] [PubMed] [Google Scholar]
- Shurin P. A., Pelton S. I., Donner A., Finkelstein J., Klein J. O. Trimethoprim-sulfamethoxazole compared with ampicillin in the treatment of acute otitis media. J Pediatr. 1980 Jun;96(6):1081–1087. doi: 10.1016/s0022-3476(80)80649-4. [DOI] [PubMed] [Google Scholar]