Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1970 Nov 7;4(5731):334–337. doi: 10.1136/bmj.4.5731.334

Further Observations on the Diurnal Variation in Oral Glucose Tolerance

R J Jarrett, H Keen
PMCID: PMC1819690  PMID: 5472804

Abstract

Diurnal variation in oral glucose tolerance was studied in 122 male volunteers aged 40 yearsand over who participated in a screening health examination. In those with screening blood sugar levels exceeding 110 mg./100 ml. the degree of diurnal variation was least in those with the highest morning glycaemia; the latter also tended to have lower afternoon fasting bloodsugar levels.

In a group of 40 control subjects, afternoon glucose tolerance tests yielded significantly higher post-glucose blood sugar levels. The degree of diurnal variation was significantly and inversely related to the degree of obesity.

Full text

PDF
334

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowen A. J., Reeves R. L. Diurnal variation in glucose tolerance. Arch Intern Med. 1967 Mar;119(3):261–264. [PubMed] [Google Scholar]
  2. CONN J. W., FAJANS S. S., SELTZER H. S. Spontaneous hypoglycemia as an early manifestation of diabetes mellitus. Diabetes. 1956 Nov-Dec;5(6):437–442. doi: 10.2337/diab.5.6.437. [DOI] [PubMed] [Google Scholar]
  3. Faiman C., Moorhouse J. A. Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111–126. [PubMed] [Google Scholar]
  4. Faludi G., Bendersky G., Gerber P. Functional hypoglycemia in early latent diabetes. Ann N Y Acad Sci. 1968 Mar 26;148(3):868–874. doi: 10.1111/j.1749-6632.1968.tb27760.x. [DOI] [PubMed] [Google Scholar]
  5. HAYNER N. S., KJELSBERG M. O., EPSTEIN F. H., FRANCIS T., Jr CARBOHYDRATE TOLERANCE AND DIABETES IN A TOTAL COMMUNITY, TECUMSEH, MICHIGAN. 1. EFFECTS OF AGE, SEX, AND TEST CONDITIONS ON ONE-HOUR GLUCOSE TOLERANCE IN ADULTS. Diabetes. 1965 Jul;14:413–423. doi: 10.2337/diab.14.7.413. [DOI] [PubMed] [Google Scholar]
  6. Jarrett R. J., Keen H. Diurnal variation of oral glucose tolerance: a possible pointer to the evolution of diabetes mellitus. Br Med J. 1969 May 10;2(5653):341–344. doi: 10.1136/bmj.2.5653.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Keen H. The presymptomatic diagnosis of diabetes. Proc R Soc Med. 1966 Nov;59(11 Pt 2):1169–1174. [PMC free article] [PubMed] [Google Scholar]
  8. Marine N., Vinik A. I., Edelstein I., Jackson W. P. Diabetes, hyperglycemia and glycosuria among Indians, Malays and Africans (Bantu) in Cape Town, South Africa. Diabetes. 1969 Dec;18(12):840–857. doi: 10.2337/diab.18.12.840. [DOI] [PubMed] [Google Scholar]
  9. ROBERTS H. J. AFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM. J Am Geriatr Soc. 1964 May;12:423–472. doi: 10.1111/j.1532-5415.1964.tb05730.x. [DOI] [PubMed] [Google Scholar]
  10. Steinkamp R. C., Cohen N. L., Gaffey W. R., McKey T., Bron G., Siri W. E., Sargent T. W., Isaacs E. Measures of body fat and related factors in normal adults. II. A simple clinical method to estimate body fat and lean body mass. J Chronic Dis. 1965 Dec;18(12):1291–1307. doi: 10.1016/0021-9681(65)90162-1. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES