Abstract
In controlled trials of the beta-adrenergic blocking drugs oxprenolol and practolol in hypertension both drugs were well tolerated without side effects and caused statistically significant non-postural reduction of blood pressure. In less than half the patients on eitherdrug the reduction of blood pressure was clinically adequate. No attempt was made to compare the two drugs.
Full text
PDF![342](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f596/1819715/b95cbf104e1e/brmedj02161-0044.png)
![343](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f596/1819715/0d24a792dc07/brmedj02161-0045.png)
![344](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f596/1819715/be50716016c4/brmedj02161-0046.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barrett A. M., Crowther A. F., Dunlop D., Shanks R. G., Smith L. H. Cardio-selective beta-blockade. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;259(2):152–153. doi: 10.1007/BF00537746. [DOI] [PubMed] [Google Scholar]
- Frohlich E. D., Tarazi R. C., Dustan H. P., Page I. H. The paradox of beta-adrenergic blockade in hypertension. Circulation. 1968 Mar;37(3):417–423. doi: 10.1161/01.cir.37.3.417. [DOI] [PubMed] [Google Scholar]
- George C. F., Nagle R. E., Pentecost B. L. Practolol in treatment of angina pectoris. A double-blind trial. Br Med J. 1970 May 16;2(5706):402–404. doi: 10.1136/bmj.2.5706.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Humphreys G. S., Delvin D. G. Ineffectiveness of propranolol in hypertensive Jamaicans. Br Med J. 1968 Jun 8;2(5605):601–603. doi: 10.1136/bmj.2.5605.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paterson J. W., Dollery C. T. Effect of propranolol in mild hypertension. Lancet. 1966 Nov 26;2(7474):1148–1150. doi: 10.1016/s0140-6736(66)90471-5. [DOI] [PubMed] [Google Scholar]
- ROSE G. A., HOLLAND W. W., CROWLEY E. A. A SPHYGMOMANOMETER FOR EPIDEMIOLOGISTS. Lancet. 1964 Feb 8;1(7328):296–300. doi: 10.1016/s0140-6736(64)92408-0. [DOI] [PubMed] [Google Scholar]
- Richardson D. W., Freund J., Gear A. S., Mauck H. P., Jr, Preston L. W. Effect of propranolol on elevated arterial blood pressure. Circulation. 1968 Apr;37(4):534–542. doi: 10.1161/01.cir.37.4.534. [DOI] [PubMed] [Google Scholar]
- Sandler G., Clayton G. A. Clinical evaluation of practolol, a new cardioselective beta-blocking agent in angina pectoris. Br Med J. 1970 May 16;2(5706):399–402. doi: 10.1136/bmj.2.5706.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilson D. F., Watson O. F., Peel J. S., Langley R. B., Turner A. S. Some haemodynamic effects of trasicor (Ciba 39,089-Ba). N Z Med J. 1968 Sep;68(436):145–149. [PubMed] [Google Scholar]
- Zacharias F. J., Cowen K. J. Controlled trial of propranolol in hypertension. Br Med J. 1970 Feb 21;1(5694):471–474. doi: 10.1136/bmj.1.5694.471. [DOI] [PMC free article] [PubMed] [Google Scholar]