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. 1970 Oct 24;4(5729):210–212. doi: 10.1136/bmj.4.5729.210

Antilymphocyte Serum and Tissue Culture Used to Investigate Role of Cell-mediated Response in Viral Encephalitis in Mice

G A W Rook, H E Webb
PMCID: PMC1819743  PMID: 5472783

Abstract

Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C. Cell-mediated immune responses to virus infections and virus-induced tumours. Br Med Bull. 1967 Jan;23(1):60–65. doi: 10.1093/oxfordjournals.bmb.a070518. [DOI] [PubMed] [Google Scholar]
  2. BERG O., KAELLEN B. EFFECT OF MONONUCLEAR BLOOD CELLS FROM MULTIPLE SCLEROSIS PATIENTS ON NEUROGLIA IN TISSUE CULTURE. J Neuropathol Exp Neurol. 1964 Jul;23:550–559. doi: 10.1097/00005072-196407000-00010. [DOI] [PubMed] [Google Scholar]
  3. Burnet F. M. Measles as an index of immunological function. Lancet. 1968 Sep 14;2(7568):610–613. doi: 10.1016/s0140-6736(68)90701-0. [DOI] [PubMed] [Google Scholar]
  4. East J., De Sousa M. A., Prosser P. R., Jaquet H. Malignant changes in New Zealand black mice. Clin Exp Immunol. 1967 Jul;2(4):427–443. [PMC free article] [PubMed] [Google Scholar]
  5. FLICK J. A., PINCUS W. B. Inhibition of the lesions of primary vaccinia and of delayed hypersensitivity through immunological tolerance in rabbits. J Exp Med. 1963 Apr 1;117:633–646. doi: 10.1084/jem.117.4.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Martin W. J., Miller J. F. Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin. J Exp Med. 1968 Oct 1;128(4):855–874. doi: 10.1084/jem.128.4.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ROSENAU W., MOON H. D. Lysis of homologous cells by sensitized lymphocytes in tissue culture. J Natl Cancer Inst. 1961 Aug;27:471–483. [PubMed] [Google Scholar]
  8. Rogers N. G., Basnight M., Gibbs C. J., Gajdusek D. C. Latent viruses in chimpanzees with experimental kuru. Nature. 1967 Nov 4;216(5114):446–449. doi: 10.1038/216446a0. [DOI] [PubMed] [Google Scholar]
  9. Ruddle N. H., Waksman B. H. Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. I. Characterization of the phenomenon. J Exp Med. 1968 Dec 1;128(6):1237–1254. doi: 10.1084/jem.128.6.1237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. WEIGAND H., HOTCHIN J. Studies of lymphocytic choriomeningitis in mice. II. A comparison of the immune status of newborn and adult mice surviving inoculation. J Immunol. 1961 Apr;86:401–406. [PubMed] [Google Scholar]
  11. Webb H. E., Wight D. G., Wiernik G., Platt G. S., Smith C. E. Langat virus encephalitis in mice. II. The effect of irradiation. J Hyg (Lond) 1968 Sep;66(3):355–364. doi: 10.1017/s002217240004122x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Williams T. W., Granger G. A. Lymphocyte in vitro cytotoxicity: lymphotoxins of several mammalian species. Nature. 1968 Sep 7;219(5158):1076–1077. doi: 10.1038/2191076a0. [DOI] [PubMed] [Google Scholar]
  13. Zlotnik I. The reaction of astrocytes to acute virus infections of the central nervous system. Br J Exp Pathol. 1968 Dec;49(6):555–564. [PMC free article] [PubMed] [Google Scholar]

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