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. 1970 Oct 17;4(5728):145–148. doi: 10.1136/bmj.4.5728.145

Controlled Clinical Trial of Combined Triiodothyronine and Thyroxine in the Treatment of Hypothyroidism

R N Smith, S A Taylor, J C Massey
PMCID: PMC1819870  PMID: 4097650

Abstract

A -double-blind crossover trial of a combined preparation of triiodothyronine and thyroxine (1:4 ratio) compared with thyroxine alone was conducted with 99 patients previously stabilized on. thyroxine as treatment for hypothyroidism. Four patients were excluded during the trial and eight afterwards owing to gross deficiencies in taking the tablets. Of the remaining 87 patients 42 (48%) had no -preference for either medication, 29 (33%) preferred thyroxine alone, and 16 (18%) the combination. A high incidence of unpleasant symptoms was experienced during the two months' treatment with the combined preparation. The serum protein-bound iodine levels were lowered (mean reduction 1·8 μg./100 ml.) on the combination, but the labelled T3-resin sponge uptake values were not altered and remained in the normal range. on both treatments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alley R. A., Danowski T. S., Robbins T. J., Weir T. F., Sabeh G., Moses C. L. Indices during administration of T4 and T3 to euthyroid adults. Metabolism. 1968 Feb;17(2):97–104. doi: 10.1016/0026-0495(68)90134-0. [DOI] [PubMed] [Google Scholar]
  2. CATZ B., GINSBURG E., SALENGER S. Clinically inactive thyroid U.S.P. A preliminary report. N Engl J Med. 1962 Jan 18;266:136–137. doi: 10.1056/NEJM196201182660308. [DOI] [PubMed] [Google Scholar]
  3. DEVLIN W. F., STEPHENSON N. R. The chemical determination of liothyronine and thyroxine in enzymic hydrolysates of pork thyroid. J Pharm Pharmacol. 1962 Sep;14:597–604. doi: 10.1111/j.2042-7158.1962.tb11144.x. [DOI] [PubMed] [Google Scholar]
  4. Devlin W. F., Watanabe H. Thyroxin-triiodothyronine concentrations in thryoid powders. J Pharm Sci. 1966 Apr;55(4):390–393. doi: 10.1002/jps.2600550408. [DOI] [PubMed] [Google Scholar]
  5. FRAWLEY T. F., MCCLINTOCK J. C., BEEBE R. T., MARTHY G. L. Metabolic and therapeutic effects of triiodothyronine. J Am Med Assoc. 1956 Feb 25;160(8):646–652. doi: 10.1001/jama.1956.02960430036007. [DOI] [PubMed] [Google Scholar]
  6. Gatley M. S. To be taken as directed. J R Coll Gen Pract. 1968 Jul;16(1):39–44. [PMC free article] [PubMed] [Google Scholar]
  7. Goolden A. W., Gartside J. M., Sanderson C. Thyroid status in pregnancy and in women taking oral contraceptives. Lancet. 1967 Jan 7;1(7480):12–15. doi: 10.1016/s0140-6736(67)92420-8. [DOI] [PubMed] [Google Scholar]
  8. Harland W. A., Orr J. S. The role of thyroxine binding in the establishment of thyroid status. Scott Med J. 1969 Nov;14(11):375–380. doi: 10.1177/003693306901401102. [DOI] [PubMed] [Google Scholar]
  9. Hedley A. J., Flemming C. J., Chesters M. I., Michie W., Crooks J. Surgical treatment of thyrotoxicosis. Br Med J. 1970 Feb 28;1(5695):519–523. doi: 10.1136/bmj.1.5695.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kologlu S., Schwartz H. L., Carter A. C. Quantitative determination of the thyroxine, triiodothyronine, monoiodotyrosine and diiodotyrosine content of desiccated thyroid. Endocrinology. 1966 Feb;78(2):231–239. doi: 10.1210/endo-78-2-231. [DOI] [PubMed] [Google Scholar]
  11. LAVIETES P. H., EPSTEIN F. H. THYROID THERAPY OF MYXEDEMA: A COMPARISON OF VARIOUS AGENTS WITH A NOTE ON THE COMPOSITION OF THYROID SECRETION IN MAN. Ann Intern Med. 1964 Jan;60:79–87. doi: 10.7326/0003-4819-60-1-79. [DOI] [PubMed] [Google Scholar]
  12. LEVY R. P., MARSHALL J. S., MCGUIRE W. L. THE EFFECT OF THYROXINE AND TRIIODOTHYRONINE TREATMENT ON THE RESIN UPTAKE OF I-131-THYROXINE AND TRIIODOTHYRONINE. Metabolism. 1964 Jun;13:557–561. doi: 10.1016/0026-0495(64)90144-1. [DOI] [PubMed] [Google Scholar]
  13. Lemieux R., Talmage J. M. The determination of liothyronine and thyroxine in thyroid preparations. J Pharm Pharmacol. 1966 Feb;18(2):94–100. doi: 10.1111/j.2042-7158.1966.tb07830.x. [DOI] [PubMed] [Google Scholar]
  14. MACGREGOR A. G. Why does anybody use thyroid B.P.? Lancet. 1961 Feb 11;1(7172):329–332. doi: 10.1016/s0140-6736(61)91498-2. [DOI] [PubMed] [Google Scholar]
  15. MITCHELL M. L., HARDEN A. B., O'ROURKE M. E. The in vitro resin sponge uptake of triiodothyronine-I-131 from serum in thyroid disease and in pregnancy. J Clin Endocrinol Metab. 1960 Nov;20:1474–1483. doi: 10.1210/jcem-20-11-1474. [DOI] [PubMed] [Google Scholar]
  16. PILEGGI V. J., GOLUB O. J., LEE N. D. DETERMINATION OF THYROXINE AND TRIIODOTHYRONINE IN COMMERCIAL PREPARATIONS OF DESICCATED THYROID AND THYROID EXTRACT. J Clin Endocrinol Metab. 1965 Jul;25:949–956. doi: 10.1210/jcem-25-7-949. [DOI] [PubMed] [Google Scholar]
  17. Porter A. M. Drug defaulting in a general practice. Br Med J. 1969 Jan 25;1(5638):218–222. doi: 10.1136/bmj.1.5638.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sachs B. A., Wolfman L., Murthy G. Lipid and clinical response to a new thyroid hormone combination. Am J Med Sci. 1968 Oct;256(4):232–238. doi: 10.1097/00000441-196810000-00004. [DOI] [PubMed] [Google Scholar]
  19. Taylor S., Kapur M., Adie R. Combined thyroxine and triiodothyronine for thyroid replacement therapy. Br Med J. 1970 May 2;2(5704):270–271. doi: 10.1136/bmj.2.5704.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WIBERG G. S., DEVLIN W. F., STEPHENSON N. R., CARTER J. R., BAYNE A. J. A comparison of the thyroxine: tri-iodothyronine content and biological activity of thyroid from various species. J Pharm Pharmacol. 1962 Dec;14:777–783. doi: 10.1111/j.2042-7158.1962.tb11176.x. [DOI] [PubMed] [Google Scholar]
  21. Wool M. S., Selenkow H. A. Physiologic combinations of synthetic thyroid hormones in myxedema. Clin Pharmacol Ther. 1965 Nov-Dec;6(6):710–715. doi: 10.1002/cpt196566710. [DOI] [PubMed] [Google Scholar]

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