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. 1970 Nov 14;4(5732):401–403. doi: 10.1136/bmj.4.5732.401

Spironolactone Diuresis in Patients with Cirrhosis and Ascites

Ronald C Eggert
PMCID: PMC1819973  PMID: 5481518

Abstract

Increased aldosterone levels with consequent or diuretic-potentiated electrolyte abnormalities are an important consideration when patients with cirrhosis and ascites undergo diuresis. A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined. Patients with a ratio greater than 1 responded well to 100 mg. of spironolactone a day; those when it was one or less responded well to 200 to 1,000 mg. a day.

Administration of spironolactone alone (11 patients) or as the main diuretic (three patients) was a safe and effective means of inducing sustained uncomplicated diuresis in all these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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