Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1982 May;21(5):718–720. doi: 10.1128/aac.21.5.718

Comparative effects of moxalactam and gentamicin on human polymorphonuclear leukocyte functions.

C Burgaleta, J Martínez-Beltrán, E Bouza
PMCID: PMC181999  PMID: 6213194

Abstract

The in vitro effects of moxalactam and gentamicin on chemotactic, phagocytic, and microbicidal activities of human polymorphonuclear leukocytes have been studied. Incubation of cells with moxalactam (25 to 400 micrograms/ml) resulted in a 10 to 15% inhibition of leukocyte chemotaxis (P less than or equal to 0.10). Incubation of cells with gentamicin (5 to 40 micrograms/ml) inhibited chemotaxis more than 50% (P less than or equal to 0.50). Neither moxalactam nor gentamicin had any effect on phagocytic or microbicidal capacities of leukocytes.

Full text

PDF
718

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J. W. Antibiotic agents and the immune mechanisms of defense. Bull N Y Acad Med. 1975 Oct;51(9):1039–1045. [PMC free article] [PubMed] [Google Scholar]
  2. DOWNEY R. J., PISANO J. C. SOME EFFECTS OF ANTIMICROBIAL COMPOUNDS ON PHAGOCYTOSIS IN VITRO. J Reticuloendothel Soc. 1965 May;2:75–88. [PubMed] [Google Scholar]
  3. Finch R. Immunomodulating effects of antimicrobial agents. J Antimicrob Chemother. 1980 Nov;6(6):691–694. doi: 10.1093/jac/6.6.691. [DOI] [PubMed] [Google Scholar]
  4. Forsgren A., Schmeling D. Effect of antibiotics of chemotaxis of human leukocytes. Antimicrob Agents Chemother. 1977 Apr;11(4):580–584. doi: 10.1128/aac.11.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Forsgren A., Schmeling D., Quie P. G. Effect of tetracycline on the phagocytic function of human leukocytes. J Infect Dis. 1974 Oct;130(4):412–415. doi: 10.1093/infdis/130.4.412. [DOI] [PubMed] [Google Scholar]
  6. Goodhart G. L. Effect of aminoglycosides on the chemotactic response of human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1977 Oct;12(4):540–542. doi: 10.1128/aac.12.4.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoeprich P. D., Martin C. H. Effect of tetracycline, polymyxin B, and rifampin on phagocytosis. Clin Pharmacol Ther. 1970 May-Jun;11(3):418–422. doi: 10.1002/cpt1970113418. [DOI] [PubMed] [Google Scholar]
  8. Khan A. J., Evans H. E., Glass L., Khan P., Chang C. T., Nair S. R. Abnormal neutrophil chemotaxis and random migration induced by aminoglycoside antibiotics. J Lab Clin Med. 1979 Feb;93(2):295–300. [PubMed] [Google Scholar]
  9. Lehrer R. I. Effects of colchicine and chloramphenicol on the oxidative metabolism and phagocytic activity of human neutrophils. J Infect Dis. 1973 Jan;127(1):40–48. doi: 10.1093/infdis/127.1.40. [DOI] [PubMed] [Google Scholar]
  10. Majeski J. A., Alexander J. W. Evaluation of tetracycline in the neutrophil chemotactic response. J Lab Clin Med. 1977 Aug;90(2):259–265. [PubMed] [Google Scholar]
  11. Majeski J. A., McClellan M. A., Alexander J. W. Effect of antibiotics on the in vitro neutrophil chemotactic response. Am Surg. 1976 Oct;42(10):785–788. [PubMed] [Google Scholar]
  12. Majeski J. A., Morris M. J., Alexander J. W. Action of cefoxitin and cefamandole on human neutrophil function. J Antibiot (Tokyo) 1978 Oct;31(10):1059–1062. doi: 10.7164/antibiotics.31.1059. [DOI] [PubMed] [Google Scholar]
  13. Martin R. R., Warr G. A., Couch R. B., Yeager H., Knight V. Effects of tetracycline on leukotaxis. J Infect Dis. 1974 Feb;129(2):110–116. doi: 10.1093/infdis/129.2.110. [DOI] [PubMed] [Google Scholar]
  14. Nelson R. D., Quie P. G., Simmons R. L. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975 Dec;115(6):1650–1656. [PubMed] [Google Scholar]
  15. Seklecki M. M., Quintiliani R., Maderazo E. G. Aminoglycoside antibiotics moderately impair granulocyte function. Antimicrob Agents Chemother. 1978 Mar;13(3):552–554. doi: 10.1128/aac.13.3.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Welch W. D., Davis D., Thrupp L. D. Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function. Antimicrob Agents Chemother. 1981 Jul;20(1):15–20. doi: 10.1128/aac.20.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES