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. 1970 Nov 28;4(5734):525–527. doi: 10.1136/bmj.4.5734.525

Effects of Large Doses of Colistin Sulphomethate Sodium on Renal Function

D J E Price, D I Graham
PMCID: PMC1820005  PMID: 5483321

Abstract

High doses of colistin were used in the treatment of severely ill patients with refractory klebsiella chest and urinary tract infections. At the same time renal function was monitored to determine possible nephrotoxicity. In all patients it produced acute renal failure and in some acute tubular necrosis. Though renal failure contributed to the final cause of death in some cases, in the majority death was due to the primary neurological illness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brauninger G. E., Remington J. S. Nephropathy associated with methicillin therapy. JAMA. 1968 Jan 8;203(2):103–105. [PubMed] [Google Scholar]
  2. Briggs J. D., Kennedy A. C., Young L. N., Luke R. G., Gray M. Renal function after acute tubular necrosis. Br Med J. 1967 Aug 26;3(5564):513–516. doi: 10.1136/bmj.3.5564.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown J. J., Gleadle R. I., Lawson D. H., Lever A. F., Linton A. L., Macadam R. F., Prentice E., Tree M., Robertson J. I. Renin and acute renal failure: studies in man. Br Med J. 1970 Jan 31;1(5691):253–258. doi: 10.1136/bmj.1.5691.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brumfitt W., Black M., Williams J. D. Colistin in Pseudomonas pyocycanea infections and its effect on renal function. Br J Urol. 1966 Oct;38(5):495–500. doi: 10.1111/j.1464-410x.1966.tb09743.x. [DOI] [PubMed] [Google Scholar]
  5. COLLEY E. W., FRANKEL H. L. "COLOMYCIN" TREATMENT OF KLEBSIELLA AEROGENES INFECTION OF URINARY TRACT IN PARAPLEGIA. Br Med J. 1963 Sep 28;2(5360):790–792. doi: 10.1136/bmj.2.5360.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Caldwell A. D., Martin A. J., Trigger D. J. Comparative study of the effect of three antibiotics on renal function. Br J Pharmacol. 1969 Sep;37(1):283–293. doi: 10.1111/j.1476-5381.1969.tb09545.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elwood C. M., Lucas G. D., Muehrcke R. C. Acute renal failure associated with sodium colistimethate treatment. Arch Intern Med. 1966 Oct;118(4):326–334. [PubMed] [Google Scholar]
  8. FINCKH E. S., JEREMY D., WHYTE H. M. Structural renal damage and its relatin to clinical features in acute oliguric renal failure. Q J Med. 1962 Oct;31:429–446. [PubMed] [Google Scholar]
  9. SEVITT S. Pathogenesis of traumatic uraemia: a revised concept. Lancet. 1959 Aug 22;2(7095):135–141. doi: 10.1016/s0140-6736(59)90557-4. [DOI] [PubMed] [Google Scholar]
  10. Schrier R. W., Bulger R. J., VanArsdel P. P., Jr Nephropathy associated with penicillin and homologues. Ann Intern Med. 1966 Jan;64(1):116–127. doi: 10.7326/0003-4819-64-1-116. [DOI] [PubMed] [Google Scholar]
  11. TALLGREN L. G., LIEWENDAHL K., KUHLBAECK B. THE THERAPEUTIC SUCCESS AND NEPHROTOXICITY OF COLISTIN IN ACUTE AND CHRONIC NEPHROPATHIES WITH IMPAIRED RENAL FUNCTION. Acta Med Scand. 1965 Jun;177:717–728. doi: 10.1111/j.0954-6820.1965.tb01882.x. [DOI] [PubMed] [Google Scholar]
  12. Vinnicombe J., Stamey T. A. The relative nephrotoxicities of polymyxin B sulfate, sodium sulfomethyl-polymyxin B, sodium sulfomethyl-colistin (colymycin), and neomycin sulfate. Invest Urol. 1969 Mar;6(5):505–519. [PubMed] [Google Scholar]
  13. YOW E. M., TAN E., SHANE L., SCHONFELD S., ABU-NASSAR H. Colistin (coly-mycin) in resistant bacterial infections. A clinical appraisal. Arch Intern Med. 1961 Nov;108:664–670. doi: 10.1001/archinte.1961.03620110004002. [DOI] [PubMed] [Google Scholar]

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