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. 1970 Dec 5;4(5735):579–582. doi: 10.1136/bmj.4.5735.579

Effects of Isoprenaline Plus Phenylephrine by Pressurized Aerosol on Blood Gases, Ventilation, and Perfusion in Chronic Obstructive Lung Disease

L H Harris
PMCID: PMC1820193  PMID: 4922094

Abstract

The effects of a combined isoprenaline-phenylephrine inhalant in chronic obstructive lung disease were assessed in 23 patients. Significant changes occurred in blood gas tensions after inhalation, together with an overall improvement in ventilation/perfusion ratios. Cardiac output and physiological shunt were not significantly increased. Hence the addition of phenylephrine probably prevents the increase of hypoxaemia which may result from the disproportionate ventilation/perfusion ratio produced by sympathomimetics or xanthines used alone. The combination aerosol has a satisfactory bronchodilator effect, and is additionally safe if used by a severely hypoxic patient unaware of the seriousness of his condition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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