Abstract
An agar diffusion assay in capillaries, with Fusobacterium nucleatum M2 as the indicator strain, has been developed to measure metronidazole concentrations in gingival crevice fluid. The assay allows the measurement of 1.9 micrograms of metronidazole per ml in sample amounts of 0.6 microliters.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Edwards R. O., Bandyopadhyay S. Physical and mechanical properties of endodontic absorbent paper points. J Endod. 1981 Mar;7(3):123–127. doi: 10.1016/S0099-2399(81)80126-4. [DOI] [PubMed] [Google Scholar]
- Gordon J. M., Walker C. B., Goodson J. M., Socransky S. S. Sensitive assay for measuring tetracycline levels in gingival crevice fluid. Antimicrob Agents Chemother. 1980 Feb;17(2):193–198. doi: 10.1128/aac.17.2.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gulaid A., Houghton G. W., Lewellen O. R., Smith J., Thorne P. S. Determination of metronidazole and its two major metabolites in biological fluids by high pressure liquid chromatography. Br J Clin Pharmacol. 1978 Nov;6(5):430–432. doi: 10.1111/j.1365-2125.1978.tb04608.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levison M. E. Microbiological agar diffusion assay for metronidazole concentrations in serum. Antimicrob Agents Chemother. 1974 May;5(5):466–468. doi: 10.1128/aac.5.5.466. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Midha K. K., McGilveray I. J., Cooper J. K. Determination of therapeutic levels of metronidazole in plasma by gas-liquid chromatography. J Chromatogr. 1973 Dec 19;87(2):491–497. doi: 10.1016/s0021-9673(01)91751-0. [DOI] [PubMed] [Google Scholar]
- Ralph E. D., Kirby W. M. Bioassay of metronidazole with either anaerobic or aerobic incubation. J Infect Dis. 1975 Nov;132(5):587–591. doi: 10.1093/infdis/132.5.587. [DOI] [PubMed] [Google Scholar]
- Schwartz D. E., Jeunet F. Comparative pharmacokinetic studies of ornidazole and metronidazole in man. Chemotherapy. 1976;22(1):19–29. doi: 10.1159/000221906. [DOI] [PubMed] [Google Scholar]
- Wheeler L. A., De Meo M., Halula M., George L., Heseltine P. Use of high-pressure liquid chromatography to determine plasma levels of metronidazole and metabolites after intravenous administration. Antimicrob Agents Chemother. 1978 Feb;13(2):205–209. doi: 10.1128/aac.13.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]