Abstract
The concentrations of sulbenicillin in maternal and fetal blood and in the amniotic fluid compartment were measured in 27 women at parturition. With an intramuscular injection of 2,000 mg of sulbenicillin, the highest concentration of sulbenicillin in maternal blood (109.0 micrograms/ml) was attained at 55 min. The highest concentrations in umbilical cord blood (approximately 25 micrograms/ml) were attained between 1 and 3 h after dosage. The peak concentration in amniotic fluid (27.1 micrograms/ml) was attained approximately 7.5 h after sulbenicillin administration.
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Selected References
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- Bray R. E., Boe R. W., Johnson W. L. Transfer of ampicillin into fetus and amniotic fluid from maternal plasma in late pregnancy. Am J Obstet Gynecol. 1966 Dec 1;96(7):938–942. doi: 10.1016/0002-9378(66)90438-8. [DOI] [PubMed] [Google Scholar]
- EAGLE H., FLEISCHMAN R., MUSSELMAN A. D. Effect of schedule of administration on the therapeutic efficacy of penicillin; importance of the aggregate time penicillin remains at effectively bactericidal levels. Am J Med. 1950 Sep;9(3):280–299. doi: 10.1016/0002-9343(50)90425-6. [DOI] [PubMed] [Google Scholar]
- MacAulay M. A., Abou-Sabe M., Charles D. Placental transfer of ampicillin. Am J Obstet Gynecol. 1966 Dec 1;96(7):943–950. doi: 10.1016/0002-9378(66)90439-x. [DOI] [PubMed] [Google Scholar]
- Tsuchiya K., Oishi T., Iwagishi C., Iwahi T. In vitro antibacterial activity of disodium -sulfobenzylpenicillin. J Antibiot (Tokyo) 1971 Sep;24(9):607–619. doi: 10.7164/antibiotics.24.607. [DOI] [PubMed] [Google Scholar]