In the January 2007 issue of the Journal, in the article entitled “Infantile Encephalopathy and Defective Mitochondrial DNA Translation in Patients with Mutations in Mitochondrial Elongation Factors EFG1 and EFTu” by Valente et al. (80:44–58), the EFTu modeling shown in panels C and D of figure 5 contains a mistake. The position of Arg339 of the human EFTu sequence (NP_003312) was erroneously exchanged with that of Arg391. The figure presented here shows the Arg339 in the correct position. Panels A and B, which refer to mitochondrial EFG1, are unchanged. The authors regret the errors.
Figure 5. .
Modeling of mitochondrial EFG1 (A and B) and EFTu (C and D). In panel A, the EFG1 GDP-binding site and the wild-type M496 residue are indicated. In panel B, the pocket containing the M496 of EFG1 is magnified, and acidic, basic, and apolar residues are in red, blue, and gray, respectively. In panel C, the three domains and the Arg339 residue of EFTu are labeled. In panel D, the model structure of human EFTu/tRNA complex is shown. The tRNA is in blue. The binding site for tRNA is magnified; note the position of the Arg339 residue, which is labeled for clarity.