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. 1993 Nov;59(11):3934–3937. doi: 10.1128/aem.59.11.3934-3937.1993

Presence of Tetrodotoxin and Tetrodotoxin-Producing Bacteria in Freshwater Sediments

H K Do 1,†, K Hamasaki 1, K Ohwada 1, U Simidu 1,‡, T Noguchi 1, Y Shida 1, K Kogure 1,*
PMCID: PMC182553  PMID: 16349096

Abstract

The occurrence of tetrodotoxin (TTX) in sediment from Lake Suwa, Japan, was confirmed by a tissue culture assay, high-performance liquid chromatography, and gas chromatography-mass spectrometry. Altogether, 17 TTX-producing bacteria belonging to five genera were isolated from Lake Suwa and Pond Inokasira. Our results indicate that TTX and TTX-producing bacteria occur even in freshwater environments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN M. S., MOSHER H. S. Tarichatoxin: isolation and purification. Science. 1963 Apr 19;140(3564):295–296. doi: 10.1126/science.140.3564.295. [DOI] [PubMed] [Google Scholar]
  2. Colquhoun D., Henderson R., Ritchie J. M. The binding of labelled tetrodotoxin to non-myelinated nerve fibres. J Physiol. 1972 Dec;227(1):95–126. doi: 10.1113/jphysiol.1972.sp010022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Do H. K., Kogure K., Simidu U. Identification of deep-sea-sediment bacteria which produce tetrodotoxin. Appl Environ Microbiol. 1990 Apr;56(4):1162–1163. doi: 10.1128/aem.56.4.1162-1163.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Evans M. H. Tetrodotoxin, saxitoxin, and related substances: their applications in neurobiology. Int Rev Neurobiol. 1972;15:83–166. doi: 10.1016/s0074-7742(08)60329-3. [DOI] [PubMed] [Google Scholar]
  5. Kim Y. H., Brown G. B., Mosher F. A. Tetrodotoxin: Occurrence in atelopid frogs of Costa Rica. Science. 1975 Jul 11;189(4197):151–152. doi: 10.1126/science.1138374. [DOI] [PubMed] [Google Scholar]
  6. Kogure K., Tamplin M. L., Simidu U., Colwell R. R. A tissue culture assay for tetrodotoxin, saxitoxin and related toxins. Toxicon. 1988;26(2):191–197. doi: 10.1016/0041-0101(88)90171-7. [DOI] [PubMed] [Google Scholar]
  7. MOSHER H. S., FUHRMAN F. A., BUCHWALD H. D., FISCHER H. G. TARICHATOXIN--TETRODOTOXIN: A POTENT NEUROTOXIN. Science. 1964 May 29;144(3622):1100–1110. doi: 10.1126/science.144.3622.1100. [DOI] [PubMed] [Google Scholar]
  8. Miyazawa K., Jeon J. K., Maruyama J., Noguchi T., Ito K., Hashimoto K. Occurrence of tetrodotoxin in the flatworm Planocera multitentaculata. Toxicon. 1986;24(7):645–650. doi: 10.1016/0041-0101(86)90027-9. [DOI] [PubMed] [Google Scholar]
  9. Noguchi T., Hashimoto Y. Isolation of tetrodotoxin from a goby Gobius criniger. Toxicon. 1973 Apr;11(3):305–307. doi: 10.1016/0041-0101(73)90060-3. [DOI] [PubMed] [Google Scholar]
  10. Noguchi T., Jeon J. K., Arakawa O., Sugita H., Deguchi Y., Shida Y., Hashimoto K. Occurrence of tetrodotoxin and anhydrotetrodotoxin in Vibrio sp. isolated from the intestines of a xanthid crab, Atergatis floridus. J Biochem. 1986 Jan;99(1):311–314. doi: 10.1093/oxfordjournals.jbchem.a135476. [DOI] [PubMed] [Google Scholar]
  11. Sheumack D. D., Howden M. E., Spence I., Quinn R. J. Maculotoxin: a neurotoxin from the venom glands of the octopus Hapalochlaena maculosa identified as tetrodotoxin. Science. 1978 Jan 13;199(4325):188–189. doi: 10.1126/science.619451. [DOI] [PubMed] [Google Scholar]
  12. Simidu U., Kita-Tsukamoto K., Yasumoto T., Yotsu M. Taxonomy of four marine bacterial strains that produce tetrodotoxin. Int J Syst Bacteriol. 1990 Oct;40(4):331–336. doi: 10.1099/00207713-40-4-331. [DOI] [PubMed] [Google Scholar]
  13. Simidu U., Noguchi T., Hwang D. F., Shida Y., Hashimoto K. Marine bacteria which produce tetrodotoxin. Appl Environ Microbiol. 1987 Jul;53(7):1714–1715. doi: 10.1128/aem.53.7.1714-1715.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]

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