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. 1991 Jan;57(1):327–330. doi: 10.1128/aem.57.1.327-330.1991

Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum.

Y Nakano 1, M Shirai 1, N Mori 1, M Nakano 1
PMCID: PMC182708  PMID: 2036020

Abstract

Microcystis aeruginosa is a common cyanobacterium in water blooms that appear widely in nutrient-rich, fresh, and brackish waters, and its toxic blooms cause the death of domestic animals. The administration of a crude toxic cell extract of M. aeruginosa K-139 to mice can produce tumor necrosis factor (TNF) and prompt severe physiological disturbances, especially liver damage, which can lead to death. The in vitro production of TNF-alpha by peritoneal macrophages was observed after stimulation with the cell extract or the purified toxin from K-139 cells. The expression of a TNF-alpha mRNA was also detected in spleen cells and peritoneal macrophages after stimulation with the cell extract. However, a previous injection of rabbit anti-murine TNF-alpha serum could prevent the liver damage to some extent and protect the mice from death. These findings indicate the involvement of TNF in microcystin shock.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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