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. 1992 Oct;58(10):3343–3346. doi: 10.1128/aem.58.10.3343-3346.1992

Evaluation of synergism among Bacillus thuringiensis toxins.

B E Tabashnik 1
PMCID: PMC183101  PMID: 1444368

Abstract

A simple test for synergism among toxins is described and applied to previously reported data on independent and joint toxicities of insecticidal proteins from Bacillus thuringiensis. The analysis shows synergism between a 27-kDa (CytA) toxin and 130- or 65-kDa (CryIV) toxins from B. thuringiensis subsp. israelensis against Aedes aegypti larvae. No positive synergism between 130- and 65-kDa toxins or among three CryIA toxins tested against seven species of Lepidoptera occurred. Comparisons with the original interpretations of these data show one case in which synergism occurred but was reported previously as absent and two cases that were not synergistic but were reported previously as suggestive of synergism. These results show that lack of an appropriate test for synergism can produce misleading conclusions. The methods described here can be used to test for synergistic effects of any poisons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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