Abstract
There is no single, simple test with which to evaluate new treatments for heart failure. Various methods need to be used, and a study of both the acute haemodynamic and longer term symptomatic effects of flosequinan, a new direct acting arteriolar and venous vasodilator, was therefore carried out in patients with heart failure. In one group of patients flosequinan increased cardiac output and caused a fall in pulmonary capillary wedge pressure, both effects lasting for 24 hours. In a double blind, placebo controlled study in another group flosequinan improved mean exercise tolerance from 9.9 to 12.7 minutes after four weeks of treatment. The drug also reduced perceived exertion during submaximal exercise and increased calf and therefore skeletal muscle blood flow. It reduced plasma renin activity and noradrenaline concentrations. Flosequinan possesses all the important properties of a drug likely to be of value in the treatment of heart failure.
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Selected References
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- Bayliss J., Norell M. S., Canepa-Anson R., Reid C., Poole-Wilson P., Sutton G. Clinical importance of the renin-angiotensin system in chronic heart failure: double blind comparison of captopril and prazosin. Br Med J (Clin Res Ed) 1985 Jun 22;290(6485):1861–1865. doi: 10.1136/bmj.290.6485.1861. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cowley A. J., Rowley J. M., Stainer K., Hampton J. R. Effects of captopril on abnormalities of the peripheral circulation and respiratory function in patients with severe heart failure. Lancet. 1984 Nov 17;2(8412):1120–1124. doi: 10.1016/s0140-6736(84)91557-5. [DOI] [PubMed] [Google Scholar]
- Cowley A. J., Stainer K., Rowley J. M., Hampton J. R. Abnormalities of the peripheral circulation and respiratory function in patients with severe heart failure. Br Heart J. 1986 Jan;55(1):75–80. doi: 10.1136/hrt.55.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Diggory G. L., Buckett W. R. An automated method to measure monoamines and metabolites using elevated temperature reversed phase HPLC with electrochemical detection. Application to striatal dopamine and hippocampal serotonin turnover. J Pharmacol Methods. 1984 Jun;11(3):207–217. doi: 10.1016/0160-5402(84)90039-1. [DOI] [PubMed] [Google Scholar]
- Franciosa J. A., Goldsmith S. R., Cohn J. N. Contrasting immediate and long-term effects of isosorbide dinitrate on exercise capacity in congestive heart failure. Am J Med. 1980 Oct;69(4):559–566. doi: 10.1016/0002-9343(80)90468-4. [DOI] [PubMed] [Google Scholar]
- Francis G. S., Siegel R. M., Goldsmith S. R., Olivari M. T., Levine T. B., Cohn J. N. Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis. Ann Intern Med. 1985 Jul;103(1):1–6. doi: 10.7326/0003-4819-103-1-1. [DOI] [PubMed] [Google Scholar]
- Mettauer B., Rouleau J. L., Bichet D., Kortas C., Manzini C., Tremblay G., Chatterjee K. Differential long-term intrarenal and neurohormonal effects of captopril and prazosin in patients with chronic congestive heart failure: importance of initial plasma renin activity. Circulation. 1986 Mar;73(3):492–502. doi: 10.1161/01.cir.73.3.492. [DOI] [PubMed] [Google Scholar]
- Packer M. Do vasodilators prolong life in heart failure? N Engl J Med. 1987 Jun 4;316(23):1471–1473. doi: 10.1056/NEJM198706043162308. [DOI] [PubMed] [Google Scholar]
- Wynne R. D., Crampton E. L., Hind I. D. The pharmacokinetics and haemodynamics of BTS 49 465 and its major metabolite in healthy volunteers. Eur J Clin Pharmacol. 1985;28(6):659–664. doi: 10.1007/BF00607911. [DOI] [PubMed] [Google Scholar]