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. 1991 Jul;57(7):2101–2103. doi: 10.1128/aem.57.7.2101-2103.1991

Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay.

H Babich 1, E Borenfreund 1
PMCID: PMC183530  PMID: 1892400

Abstract

The neutral red (NR) cell viability assay was used with various cell types of human origin to quantitate the potency of T-2 mycotoxin and its metabolites. The human melanoma SK-Mel/27 cell line was the most sensitive, with a midpoint cytotoxicity value of 2.8 ng of T-2 per ml. With the human hepatoma cell line, HepG2, the sequence of potency for a series of mycotoxins was T-2 greater than HT-2 greater than T-2 triol greater than T-2 tetraol.

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Selected References

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