Skip to main content
NCBI home page
The BMJ logoLink to The BMJ
. 1989 Mar 4;298(6673):558–560. doi: 10.1136/bmj.298.6673.558

Incidence of insulin dependent diabetes in England: a study in the Oxford region, 1985-6.

P J Bingley 1, E A Gale 1
PMCID: PMC1835904  PMID: 2495112

Abstract

OBJECTIVE--To determine the incidence of insulin dependent diabetes mellitus up to the age of 21 in a geographically defined population in England with independent validation of completeness of case ascertainment. DESIGN--Prospective registration of newly diagnosed cases supplemented by centralised hospital discharge records and death certificates. Validation of ascertainment from general practitioners. SETTING--Oxford Regional Health Authority area (population 2.4 million). PATIENTS--All patients with insulin dependent diabetes diagnosed below age 21 during 1985-6 and resident in the region at the time of diagnosis. INTERVENTIONS--None. END POINT--Validation of a method of case ascertainment for assessing temporal variation in incidence of insulin dependent diabetes. MEASUREMENTS AND MAIN RESULTS--The overall yearly incidence of newly diagnosed insulin dependent diabetes mellitus in people under 21 was 15.6 cases/100,000 (95% confidence interval 13.6 to 17.6). Among males the incidence was 16.8 cases (14.0 to 19.7)/100,000 and among females 14.3 cases (11.6 to 17.1)/100,000. The highest incidence, in the 10-14 year age group, was 26.4 (20.9 to 31.8) new cases/100,000 population yearly. Case ascertainment was greater than 95%. CONCLUSIONS--The incidence of insulin dependent diabetes in England is considerably higher than reported from large scale studies. It is consistent with described patterns of geographical variation. The figures provide a baseline for assessing temporal change.

Full text

PDF
558

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akerblom H. K., Reunanen A. The epidemiology of insulin-dependent diabetes mellitus (IDDM) in Finland and in northern Europe. Diabetes Care. 1985 Sep-Oct;8 (Suppl 1):10–16. doi: 10.2337/diacare.8.1.s10. [DOI] [PubMed] [Google Scholar]
  2. Dahlquist G., Gustavsson K. H., Holmgren G., Hägglöf B., Larsson Y., Nilsson K. O., Samuelsson G., Sterky G., Thalme B., Wall S. The incidence of diabetes mellitus in Swedish children 0-14 years of age. A prospective study 1977-1980. Acta Paediatr Scand. 1982 Jan;71(1):7–14. doi: 10.1111/j.1651-2227.1982.tb09364.x. [DOI] [PubMed] [Google Scholar]
  3. Goldacre M. J., Simmons H., Henderson J., Gill L. E. Trends in episode based and person based rates of admission to hospital in the Oxford record linkage study area. Br Med J (Clin Res Ed) 1988 Feb 20;296(6621):583–585. doi: 10.1136/bmj.296.6621.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Green A., Andersen P. K. Epidemiological studies of diabetes mellitus in Denmark: 3. Clinical characteristics and incidence of diabetes among males aged 0 to 19 years. Diabetologia. 1983 Sep;25(3):226–230. doi: 10.1007/BF00279933. [DOI] [PubMed] [Google Scholar]
  5. Hours M., Fabry J., Siemiatycki J., Francois R. Diabéte insulino-dépendant juvénile. Etude descriptive dans le département du Rhône. Rev Epidemiol Sante Publique. 1984;32(2):107–112. [PubMed] [Google Scholar]
  6. Joner G., Søvik O. Incidence, age at onset and seasonal variation of diabetes mellitus in Norwegian children, 1973-1977. Acta Paediatr Scand. 1981;70(3):329–335. doi: 10.1111/j.1651-2227.1981.tb16560.x. [DOI] [PubMed] [Google Scholar]
  7. Kurtz Z., Peckham C. S., Ades A. E. Changing prevalence of juvenile-onset diabetes mellitus. Lancet. 1988 Jul 9;2(8602):88–90. doi: 10.1016/s0140-6736(88)90015-3. [DOI] [PubMed] [Google Scholar]
  8. North A. F., Jr, Gorwitz K., Sultz H. A. A secular increase in the incidence of juvenile diabetes mellitus. J Pediatr. 1977 Nov;91(5):706–710. doi: 10.1016/s0022-3476(77)81019-6. [DOI] [PubMed] [Google Scholar]
  9. Pagano G., Cavallo-Perin P., Cavalot F., Dall'Omo A. M., Masciola P., Suriani R., Amoroso A., Curtoni S. E., Borelli I., Lenti G. Genetic, immunologic, and environmental heterogeneity of IDDM. Incidence and 12-mo follow-up of an Italian population. Diabetes. 1987 Jul;36(7):859–863. doi: 10.2337/diab.36.7.859. [DOI] [PubMed] [Google Scholar]
  10. Patterson C. C., Smith P. G., Webb J., Heasman M. A., Mann J. I. Geographical variation in the incidence of diabetes mellitus in Scottish children during the period 1977-1983. Diabet Med. 1988 Mar;5(2):160–165. doi: 10.1111/j.1464-5491.1988.tb00964.x. [DOI] [PubMed] [Google Scholar]
  11. Rewers M., LaPorte R. E., Walczak M., Dmochowski K., Bogaczynska E. Apparent epidemic of insulin-dependent diabetes mellitus in Midwestern Poland. Diabetes. 1987 Jan;36(1):106–113. doi: 10.2337/diab.36.1.106. [DOI] [PubMed] [Google Scholar]
  12. Stewart-Brown S., Haslum M., Butler N. Evidence for increasing prevalence of diabetes mellitus in childhood. Br Med J (Clin Res Ed) 1983 Jun 11;286(6381):1855–1857. doi: 10.1136/bmj.286.6381.1855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Vaandrager G. J., Bruining G. J., Veenhof F. J., Drayer N. M. Incidence of childhood diabetes in The Netherlands: a decrease from north to south over north-western Europe? Diabetologia. 1984 Aug;27(2):203–206. doi: 10.1007/BF00273807. [DOI] [PubMed] [Google Scholar]
  14. Wilson R. M., Clarke P., Barkes H., Heller S. R., Tattersall R. B. Starting insulin treatment as an outpatient. Report of 100 consecutive patients followed up for at least one year. JAMA. 1986 Aug 15;256(7):877–880. doi: 10.1001/jama.256.7.877. [DOI] [PubMed] [Google Scholar]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES