Abstract
OBJECTIVE: To determine whether doses of the pineal hormone melatonin alleviate jet lag. DESIGN: Double blind, placebo controlled crossover trial. SETTING: Long haul return flights from Auckland, New Zealand, to London and back. SUBJECTS: Twenty volunteers with experience of transcontinental flights (eight women and 12 men aged 28 to 68). INTERVENTIONS: Melatonin (or placebo) 5 mg three days before flight, during flight, and once a day for three days after arrival. END POINT: Symptoms of jet lag. MEASUREMENTS AND MAIN RESULTS: Visual analogue scale for feelings of jet lag and tiredness; profile of moods states questionnaire for vigour-activity and fatigue-inertia; and retrospective ratings 10 days after arrival of sleep pattern, energy, and daytime tiredness. Feelings of jet lag were less for subjects taking melatonin (mean score 2.15 v 3.4); these subjects took fewer days than the placebo group to establish a normal sleep pattern (2.85 v 4.15), to not feel tired during the day (3.0 v 4.6), and to reach normal energy levels (3.25 v 4.7). Results for fatigue-inertia and vigour-activity were similar. For all subjects jet lag was more severe on the return (westward) than the outward (eastward) journey. CONCLUSIONS: Melatonin can alleviate jet lag and tiredness after long haul flights.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arendt J., Aldhous M., Marks V. Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br Med J (Clin Res Ed) 1986 May 3;292(6529):1170–1170. doi: 10.1136/bmj.292.6529.1170. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arendt J., Marks V. Can melatonin alleviate jet lag? Br Med J (Clin Res Ed) 1983 Aug 6;287(6389):426–426. doi: 10.1136/bmj.287.6389.426-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arendt J., Marks V. Physiological changes underlying jet lag. Br Med J (Clin Res Ed) 1982 Jan 16;284(6310):144–146. doi: 10.1136/bmj.284.6310.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nicholson A. N., Pascoe P. A., Spencer M. B., Stone B. M., Roehrs T., Roth T. Sleep after transmeridian flights. Lancet. 1986 Nov 22;2(8517):1205–1208. doi: 10.1016/s0140-6736(86)92207-5. [DOI] [PubMed] [Google Scholar]