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. 1989 May 20;298(6684):1363–1365. doi: 10.1136/bmj.298.6684.1363

Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis.

C F Kiire 1
PMCID: PMC1836658  PMID: 2502256

Abstract

Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p less than 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastrointestinal bleeding in patients with non-cirrhotic portal fibrosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonn J. A., Turner P., Hicks D. C. Beta-adrenergic-receptor blockade with practolol in treatment of anxiety. Lancet. 1972 Apr 15;1(7755):814–815. doi: 10.1016/s0140-6736(72)90799-4. [DOI] [PubMed] [Google Scholar]
  2. Burroughs A. K., Jenkins W. J., Sherlock S., Dunk A., Walt R. P., Osuafor T. O., Mackie S., Dick R. Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. N Engl J Med. 1983 Dec 22;309(25):1539–1542. doi: 10.1056/NEJM198312223092502. [DOI] [PubMed] [Google Scholar]
  3. Hayes P., Bouchier I. A. Drug therapy of portal hypertension and oesophageal varices. Br J Hosp Med. 1984 Jul;32(1):39–42. [PubMed] [Google Scholar]
  4. Hillon P., Lebrec D., Muńoz C., Jungers M., Goldfarb G., Benhamou J. P. Comparison of the effects of a cardioselective and a nonselective beta-blocker on portal hypertension in patients with cirrhosis. Hepatology. 1982 Sep-Oct;2(5):528–531. doi: 10.1002/hep.1840020503. [DOI] [PubMed] [Google Scholar]
  5. Kiire C. F., Kitai I., Sigola L., Ternouth I. Upper gastrointestinal bleeding in an African setting. J R Coll Physicians Lond. 1987 Apr;21(2):107–110. [PMC free article] [PubMed] [Google Scholar]
  6. Lebrec D., Nouel O., Bernuau J., Bouygues M., Rueff B., Benhamou J. P. Propranolol in prevention of recurrent gastrointestinal bleeding in cirrhotic patients. Lancet. 1981 Apr 25;1(8226):920–921. doi: 10.1016/s0140-6736(81)91617-2. [DOI] [PubMed] [Google Scholar]
  7. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Westaby D., Bihari D. J., Gimson A. E., Crossley I. R., Williams R. Selective and non-selective beta receptor blockade in the reduction of portal pressure in patients with cirrhosis and portal hypertension. Gut. 1984 Feb;25(2):121–124. doi: 10.1136/gut.25.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Westaby D., Melia W. M., Macdougall B. R., Hegarty J. E., Gimson A. E., Williams R. B1 selective adrenoreceptor blockade for the long term management of variceal bleeding. A prospective randomised trial to compare oral metoprolol with injection sclerotherapy in cirrhosis. Gut. 1985 Apr;26(4):421–425. doi: 10.1136/gut.26.4.421. [DOI] [PMC free article] [PubMed] [Google Scholar]

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