Abstract
Strains of Mycobacterium avium-intracellulare complex often exhibit in vitro resistance to common antimycobacterial agents. Combinations of etambutol, isoniazid, kanamycin, rifampin, and streptomycin were tested to determine if synergism occurred. Ninety-six percent of the strains were susceptible to a combination of ethambutol and rifampin at concentrations attainable clinically. Other combinations of antimycobacterial agents inhibited 4 to 82% of the isolates tested.
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Selected References
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- Dutt A. K., Stead W. W. Long-term results of medical treatment in Mycobacterium intracellulare infection. Am J Med. 1979 Sep;67(3):449–453. doi: 10.1016/0002-9343(79)90792-7. [DOI] [PubMed] [Google Scholar]
- Gangadharam P. R., Gonzales E. R. Influence of the medium on the in vitro susceptibility of Mycobacterium tuberculosis to ethambutol. Am Rev Respir Dis. 1970 Oct;102(4):653–655. doi: 10.1164/arrd.1970.102.4.653. [DOI] [PubMed] [Google Scholar]
- Kuze F., Takeda S., Maekawa N. [Sensitivities of atypical mycobacteria to various drugs. III. Sensitivities of M. intracellulare to antituberculous drugs in triple combinations (author's transl)]. Kekkaku. 1977 Jul;52(7):331–338. [PubMed] [Google Scholar]
- Moellering R. C., Jr Antimicrobial synergism--an elusive concept. J Infect Dis. 1979 Oct;140(4):639–641. doi: 10.1093/infdis/140.4.639. [DOI] [PubMed] [Google Scholar]
- Moulding T. The relative drug susceptibility of opaque colonial forms of Mycobacterium intracellulare-avium: does it affect therapeutic results? Am Rev Respir Dis. 1978 Jun;117(6):1142–1143. doi: 10.1164/arrd.1978.117.6.1142. [DOI] [PubMed] [Google Scholar]
- Norden C. W., Wentzel H., Keleti E. Comparison of techniques for measurement of in vitro antibiotic synergism. J Infect Dis. 1979 Oct;140(4):629–633. doi: 10.1093/infdis/140.4.629. [DOI] [PubMed] [Google Scholar]
- Rosenzweig D. Y. Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases. Chest. 1979 Feb;75(2):115–119. doi: 10.1378/chest.75.2.115. [DOI] [PubMed] [Google Scholar]
- Rynearson T. K., Shronts J. S., Wolinsky E. Rifampin: in vitro effect on atypical mycobacteria. Am Rev Respir Dis. 1971 Aug;104(2):272–274. doi: 10.1164/arrd.1971.104.2.272. [DOI] [PubMed] [Google Scholar]
- Stottmeier K. D., Woodley C. L., Kubica G. P. New approach for the evaluation of antimycobacterial drug combinations in vitro (the laboratory model man). Appl Microbiol. 1969 Sep;18(3):399–403. doi: 10.1128/am.18.3.399-403.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tisdall P. A., Roberts G. D., Anhalt J. P. Identification of clinical isolates of mycobacteria with gas-liquid chromatography alone. J Clin Microbiol. 1979 Oct;10(4):506–514. doi: 10.1128/jcm.10.4.506-514.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]