Abstract
Methyl daunosamine inhibited the replication of herpes simplex virus type 1 in a dose-dependent manner. The growth of the host Vero cells was not affected by daunosamine levels that had significant antiviral activity (2.5 mM) but was inhibited by concentrations of 5 mM or greater. Methyl daunosamine appears to be unique among the sugars with antiviral activity because at antiviral concentrations it did not inhibit the glycosylation of macromolecules.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blough H. A., Giuntoli R. L. Successful treatment of human genital herpes infections with 2-deoxy-D-glucose. JAMA. 1979 Jun 29;241(26):2798–2801. [PubMed] [Google Scholar]
- Cohen A., Harley E. H., Rees K. R. Antiviral effect of daunomycin. Nature. 1969 Apr 5;222(5188):36–38. doi: 10.1038/222036a0. [DOI] [PubMed] [Google Scholar]
- Courtney R. J., Steiner S. M., Benyesh-Melnick M. Effects of 2-deoxy-D-glucose on herpes simplex virus replication. Virology. 1973 Apr;52(2):447–455. doi: 10.1016/0042-6822(73)90340-1. [DOI] [PubMed] [Google Scholar]
- Dix R. D., Courtney R. J. Effects of cytochalasin B on herpes simplex virus type 1 replication. Virology. 1976 Mar;70(1):127–135. doi: 10.1016/0042-6822(76)90242-7. [DOI] [PubMed] [Google Scholar]
- Hodes D. S., Schnitzer T. J., Kalica A. R., Camargo E., Chanock R. M. Inhibition of Respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-D-glucose. Virology. 1975 Jan;63(1):201–208. doi: 10.1016/0042-6822(75)90385-2. [DOI] [PubMed] [Google Scholar]
- Hughes R. C., Meager A., Nairn R. Effect of 2-deoxy-D-glucose on the cell-surface glycoproteins of hamster fibroblasts,. Eur J Biochem. 1977 Jan;72(2):265–273. doi: 10.1111/j.1432-1033.1977.tb11249.x. [DOI] [PubMed] [Google Scholar]
- Kaluza G., Scholtissek C., Rott R. Inhibition of the multiplication of enveloped RNA-viruses by glucosamine and 2-deoxy-D-glucose. J Gen Virol. 1972 Mar;14(3):251–259. doi: 10.1099/0022-1317-14-3-251. [DOI] [PubMed] [Google Scholar]
- Molnar Z., Bekesi J. G. Effects of D-glucosamine, D-mannosamine, and 2-deoxy-D-glucose on the ultrastructure of ascites tumor cells in vitro. Cancer Res. 1972 Feb;32(2):380–389. [PubMed] [Google Scholar]
- Nakamura K., Compans R. W. Effects of glucosamine, 2-deoxyglucose, and tunicamycin on glycosylation, sulfation, and assembly of influenza viral proteins. Virology. 1978 Feb;84(2):303–319. doi: 10.1016/0042-6822(78)90250-7. [DOI] [PubMed] [Google Scholar]
- Schmidt M. F., Schwarz R. T., Ludwig H. Fluorosugars inhibit biological properties of different enveloped viruses. J Virol. 1976 Jun;18(3):819–823. doi: 10.1128/jvi.18.3.819-823.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schmidt M. F., Schwarz R. T., Scholtissek C. Interference of nucleoside diphosphate derivatives of 2-deoxy-D-glucose with the glycosylation of virus-specific glycoproteins in vivo. Eur J Biochem. 1976 Nov 1;70(1):55–62. doi: 10.1111/j.1432-1033.1976.tb10955.x. [DOI] [PubMed] [Google Scholar]
- Scholtissek C. Inhibition of the multiplication of enveloped viruses by glucose derivatives. Curr Top Microbiol Immunol. 1975;70:101–119. doi: 10.1007/978-3-642-66101-3_4. [DOI] [PubMed] [Google Scholar]
- Scholtissek C., Rott R., Hau G., Kaluza G. Inhibition of the multiplication of vesicular stomatitis and Newcastle disease virus by 2-deoxy-d-glucose. J Virol. 1974 Jun;13(6):1186–1193. doi: 10.1128/jvi.13.6.1186-1193.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]