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. 1982 Aug;22(2):272–276. doi: 10.1128/aac.22.2.272

Bactericidal activity of antibiotics against Legionella micdadei (Pittsburgh pneumonia agent).

J N Dowling, R S Weyant, A W Pasculle
PMCID: PMC183724  PMID: 6927637

Abstract

The bactericidal activity of five antibiotics for Legionella micdadei was determined by the construction of time-kill curves. Erythromycin, rifampin, penicillin G, cephalothin, and gentamicin were bactericidal for L. micdadei at readily achievable concentrations. The minimal bactericidal concentrations, defined as those producing 99.9% killing within 24 h, were: erythromycin, 4.6; rifampin, 0.13; penicillin G, 0.25; cephalothin, 2.5; and gentamicin, 0.25 micrograms/ml. The ratios of the minimal bactericidal to minimal inhibitory concentrations for these antibiotics ranged from 1 to 8. Thus, the poor in vivo activity of beta-lactam and aminoglycoside antibiotics against L. micdadei cannot be ascribed to a lack of killing by these agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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