Abstract
Urinary tract infection caused by beta-lactamase-producing bacteria were treated with 500 mg of amoxicillin three times daily plus either 250 or 125 mg of clavulanic acid three times daily. The overall cure rate was 63.6%, 77.7% with the high dose of clavulanic acid and 53.8% with the low dose. Gastrointestinal intolerance was common in the high-dose clavulanic acid regimen.
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Selected References
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- Ball A. P., Geddes A. M., Davey P. G., Farrell I. D., Brookes G. R. Clavulanic acid and amoxycillin: a clinical, bacteriological, and pharmacological study. Lancet. 1980 Mar 22;1(8169):620–623. doi: 10.1016/s0140-6736(80)91118-6. [DOI] [PubMed] [Google Scholar]
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Dumon L., Adriaens P., Anné J., Eyssen H. Effect of clavulanic acid on the minimum inhibitory concentration of benzylpenicillin, ampicillin, carbenicillin, or cephalothin against clinical isolates resistant to beta-lactam antibiotics. Antimicrob Agents Chemother. 1979 Feb;15(2):315–317. doi: 10.1128/aac.15.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klastersky J., Daneau D., Swings G., Weerts D. Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections. J Infect Dis. 1974 Feb;129(2):187–193. doi: 10.1093/infdis/129.2.187. [DOI] [PubMed] [Google Scholar]
- Labia R., Peduzzi J. Cinetique de l'inhibition de beta-lactamases par l'acide clavulanique. Biochim Biophys Acta. 1978 Oct 12;526(2):572–579. doi: 10.1016/0005-2744(78)90147-x. [DOI] [PubMed] [Google Scholar]
- Martinelli R., Lopes A. A., de Oliveira M. M., Rocha H. Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin. Antimicrob Agents Chemother. 1981 Dec;20(6):800–802. doi: 10.1128/aac.20.6.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matsuura M., Nakazawa H., Hashimoto T., Mitsuhashi S. Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains. Antimicrob Agents Chemother. 1980 Jun;17(6):908–911. doi: 10.1128/aac.17.6.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Minami S., Inoue M., Mitsuhashi S. Purification and properties of cephalosporinase in Escherichia coli. Antimicrob Agents Chemother. 1980 Jul;18(1):77–80. doi: 10.1128/aac.18.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C., Fu K. P. Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother. 1978 Nov;14(5):650–655. doi: 10.1128/aac.14.5.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C., Fu K. P. Synergistic activity of piperacillin in combination with beta-lactamase inhibitors. Antimicrob Agents Chemother. 1980 Oct;18(4):582–585. doi: 10.1128/aac.18.4.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ninane G., Joly J., Kraytman M., Piot P. Bronchopulmonary infection due to beta-lactamase-producing Branhamella catarrhalis treated with amoxycillin/clavulanic-acid. Lancet. 1978 Jul 29;2(8083):257–257. doi: 10.1016/s0140-6736(78)91763-4. [DOI] [PubMed] [Google Scholar]
- Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. doi: 10.1128/aac.11.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rogers D. T., Russell A. D. Combinations of clavulanic acid and other beta-lactam antibiotics against strains of Pseudomonas aeruginosa, Serratia marcescens and other bacteria. J Appl Bacteriol. 1980 Aug;49(1):111–118. doi: 10.1111/j.1365-2672.1980.tb01048.x. [DOI] [PubMed] [Google Scholar]
- Stratton C. W., Reller L. B. Serum dilution test for bactericidal activity. I. Selection of a physiologic diluent. J Infect Dis. 1977 Aug;136(2):187–195. doi: 10.1093/infdis/136.2.187. [DOI] [PubMed] [Google Scholar]
- Thomas V., Shelokov A., Forland M. Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med. 1974 Mar 14;290(11):588–590. doi: 10.1056/NEJM197403142901102. [DOI] [PubMed] [Google Scholar]
- Wise R., Andrews J. M., Bedford K. A. Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. J Antimicrob Chemother. 1980 Mar;6(2):197–206. doi: 10.1093/jac/6.2.197. [DOI] [PubMed] [Google Scholar]