Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1982 Oct;22(4):598–603. doi: 10.1128/aac.22.4.598

In vitro susceptibility and cross-resistance of South African isolates of Neisseria gonorrhoeae to 14 antimicrobial agents.

L D Liebowitz, R C Ballard, H J Koornhof
PMCID: PMC183799  PMID: 6817704

Abstract

One hundred isolates of Neisseria gonorrhoeae obtained from patients attending clinics in Johannesburg, South Africa, were tested by a broth dilution technique for their minimal inhibitory concentrations (MICs) of benzyl penicillin G, ampicillin, cefoxitin, cefuroxime, cefotaxime, ceftriaxone, ceftazidime, tetracycline, minocycline, doxycycline, spectinomycin, rosaramicin, chloramphenicol, and rosoxacin. None of the isolates tested produced beta-lactamase. The MICs of penicillin ranged from less than or equal to 0.007 to 0.5 micrograms/ml. The isolates were also very susceptible to rosaramicin (minimal concentration at which 50% of isolates were inhibited [MIC50] = 0.02 micrograms/ml) and to the new cephalosporins (cefotaxime MIC50 less than 0.007 micrograms/ml, ceftriaxone MIC50 less than 0.007 micrograms/ml, and ceftazidime MIC50 less than 0.007 micrograms/ml). By using regression analysis, good correlation was observed between the MICs of penicillin and those of the other agents, with the exception of ceftriaxone, spectinomycin, and rosaramicin. The MICs and the minimal bactericidal concentrations were within a log2 concentration of each other.

Full text

PDF
598

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biddle J. W., Thornsberry C. In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1979 Feb;15(2):243–245. doi: 10.1128/aac.15.2.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hall W. H., Schierl E. A., Maccani J. E. Comparative susceptibility of penicillinase-positive and -negative Neisseria gonorrhoeae to 30 antibiotics. Antimicrob Agents Chemother. 1979 Apr;15(4):562–567. doi: 10.1128/aac.15.4.562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  4. Jokipii A. M., Renkonen O. V. The disc and plate dilution methods in determination of the sensitivity of Neisseria gonorrhoeae to penicillin G, ampicillin and doxycycline. Chemotherapy. 1970;15(5):317–321. doi: 10.1159/000220696. [DOI] [PubMed] [Google Scholar]
  5. Ng W. S., Anton P., Arnold K. Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics. Antimicrob Agents Chemother. 1981 Jan;19(1):12–17. doi: 10.1128/aac.19.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Phillips I., King A., Warren C., Watts B. The activity of penicillin and eight cephalosporins on Neisseria gonorrhoeae. J Antimicrob Chemother. 1976 Mar;2(1):31–39. doi: 10.1093/jac/2.1.31. [DOI] [PubMed] [Google Scholar]
  8. Piot P., van Dyck E., Colaert J., Ursi J. P., Bosmans E., Meheus A. Antibiotic susceptibility of Neisseria gonorrhoeae strains from Europe and Africa. Antimicrob Agents Chemother. 1979 Apr;15(4):535–539. doi: 10.1128/aac.15.4.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rahal J. J., Jr, Simberkoff M. S. Bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens. Antimicrob Agents Chemother. 1979 Jul;16(1):13–18. doi: 10.1128/aac.16.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reyn A. Antibiotic sensitivity of gonococcal strains isolated in the South-East Asia and Western Pacific regions in 1961-68. Bull World Health Organ. 1969;40(2):257–262. [PMC free article] [PubMed] [Google Scholar]
  11. Reyn A., Benzon M. W. A study of the relationships between the sensitivities of Neisseria gonorrhoeae to sodium penicillin G, four semi-synthetic penicillins, spiramycin, and fusidic acid. Br J Vener Dis. 1968 Jun;44(2):140–150. doi: 10.1136/sti.44.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Robins-Browne R. M., Gaillard M. C., Koornhof H. J., Schneider J. Antibiotic susceptibility of Neisseria gonorrhoeae isolated in Johannesburg. S Afr Med J. 1978 Oct 7;54(15):601–603. [PubMed] [Google Scholar]
  13. Seth A. D., Kolator B., Wilkinson A. E. Sensitivity of Neisseria gonorrhoeae to antibiotics in London (1976-78). Br J Vener Dis. 1979 Oct;55(5):325–328. doi: 10.1136/sti.55.5.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Seth A. D. Sensitivity of gonococci to rosoxacin compared with that of penicillin, cefuroxime and tetracycline. J Antimicrob Chemother. 1981 Apr;7(4):331–334. doi: 10.1093/jac/7.4.331. [DOI] [PubMed] [Google Scholar]
  15. The National Gonorrhea Therapy Monitoring Study: II. Trends and seasonality of antibiotic resistance of Neisseria gonorrhoeae. Sex Transm Dis. 1979 Apr-Jun;6(2 Suppl):103–111. [PubMed] [Google Scholar]
  16. Thornsberry C., Jaffee H., Brown S. T., Edwards T., Biddle J. W., Thompson S. E. Spectinomycin-resistant Neisseria gonorrhoeae. JAMA. 1977 May 30;237(22):2405–2406. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES